The First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China.
Xinjiang Medical University, Urumqi, Xinjiang, China.
PeerJ. 2024 Sep 27;12:e18144. doi: 10.7717/peerj.18144. eCollection 2024.
Dyslipidemia plays a very important role in the occurrence and development of cardiovascular disease (CVD). Genetic factors, including single nucleotide polymorphisms (SNPs), are one of the main risks of dyslipidemia. 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is not only the rate-limiting enzyme step of endogenous cholesterol production, but also the therapeutic target of statins.
We investigated 405 Han Chinese and 373 Uyghur people who took statins for a period of time, recorded their blood lipid levels and baseline data before and after oral statin administration, and extracted DNA from each subject for SNP typing of rs17671591 and rs3761740. The effects of rs17671591 and rs3761740 on lipid levels and the effect of statins on lipid lowering in Han Chinese and Uyghur ethnic groups were studied.
In this study, for rs17671591, the CC . TT+CT model was significantly correlated with the level of LDL-C before oral statin in the Uyghur population, but there were no correlations between rs17671591 and the level of blood lipid before oral statin in the Han population. The CC . TT+CT and CT . CC+TT models were significantly correlated with the level of LDL-C after oral statin in the Uyghur population. There was no significant correlation between rs3761740 with blood lipids before and after oral statin in the Han population. For rs3761740, before oral statin, the CC . AA+CA model was significantly correlated with the level of LDL-C, and the CA . CC+AA model was significantly correlated with the level of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), and non-high density lipoprotein cholesterol (HDL-C) in the Uyghur population. After oral statin, the CC . AA+CA and CA . CC+AA models were significantly correlated with the level of TC, LDL-C, and apolipoprotein (APOB), and the C . A model was significantly correlated with the level of TC, triglyceride (TG), LDL-C, and APOB in the Uyghur population. Particularly, the CT . CC+TT model of rs17671591 was significantly correlated with the changes of LDL-C after oral statin in the Uyghur population. In this study, we also explored the association of rs17671591 and rs3761740 with the rate of dyslipidemia as a reference.
We found that rs3761740 was correlated with the levels of TC, LDL-C, and non-HDL-C before and after oral statin in Uyghurs, but not with blood lipid levels in the Han population. In the Uyghur population, rs17671591 was associated with the level of LDL-C before and after oral statin, and also affected the changes of LDL-C after oral statin.
血脂异常在心血管疾病（CVD）的发生和发展中起着非常重要的作用。遗传因素，包括单核苷酸多态性（SNP），是血脂异常的主要风险之一。3-羟基-3-甲基戊二酰基辅酶 A 还原酶（HMGCR）不仅是内源性胆固醇产生的限速酶步骤，也是他汀类药物的治疗靶点。
我们调查了 405 名汉族和 373 名维吾尔族服用他汀类药物一段时间的人群，记录了他们口服他汀类药物前后的血脂水平和基线数据，并从每位受试者中提取 DNA 进行 rs17671591 和 rs3761740 的 SNP 分型。研究了 rs17671591 和 rs3761740 对血脂水平的影响，以及他汀类药物对汉族和维吾尔族人群降脂作用的影响。
在本研究中，对于 rs17671591，CC. TT+CT 模型与维吾尔族人口口服他汀类药物前 LDL-C 水平显著相关，但汉族人口 rs17671591 与口服他汀类药物前血脂水平之间无相关性。CC. TT+CT 和 CT. CC+TT 模型与维吾尔族人口口服他汀类药物后 LDL-C 水平显著相关。rs3761740 与汉族人口口服他汀类药物前后的血脂水平无显著相关性。对于 rs3761740，在口服他汀类药物前，CC. AA+CA 模型与 LDL-C 水平显著相关，CA. CC+AA 模型与总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和非高密度脂蛋白胆固醇（HDL-C）水平显著相关。口服他汀类药物后，CC. AA+CA 和 CA. CC+AA 模型与 TC、LDL-C 和载脂蛋白（APOB）水平显著相关，C. A 模型与 TC、甘油三酯（TG）、LDL-C 和 APOB 水平显著相关。特别是，rs17671591 的 CT. CC+TT 模型与维吾尔族人口口服他汀类药物后 LDL-C 的变化显著相关。在本研究中，我们还探讨了 rs17671591 和 rs3761740 与血脂异常发生率的关联作为参考。
我们发现 rs3761740 与维吾尔族人口口服他汀类药物前后 TC、LDL-C 和非 HDL-C 水平相关，但与汉族人口血脂水平无关。在维吾尔族人群中，rs17671591 与口服他汀类药物前后的 LDL-C 水平相关，并且还影响口服他汀类药物后的 LDL-C 变化。
