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一锅法有机转化中化学选择性调控的最新趋势。

Recent trends for chemoselectivity modulation in one-pot organic transformations.

作者信息

Chaudhary Hiren R, Patel Divyang M

机构信息

Department of Chemistry, Sankalchand Patel University Visnagar 384315 Gujarat India

出版信息

RSC Adv. 2024 Sep 30;14(42):31072-31116. doi: 10.1039/d4ra05495d. eCollection 2024 Sep 24.

Abstract

In organic reactions, chemoselectivity refers to the selective reactivity of one functional group in the presence of another. This can be more successful if the reagent and reaction parameters are appropriately chosen. One-pot reactions have been shown to be an effective structural variety technique for the development of novel heterocyclic or carbocyclic compounds. This review article focuses on recent efforts by researchers from around the world to synthesise novel organic molecules utilising these methodologies (2013-2024), as well as their mechanism insights. The substrate, catalyst, solvent, and temperature conditions all have a significant impact on chemoselectivity in the organic reactions described here. The manipulation of chemoselectivity in organic processes creates new potential for the production of novel heterocycles and carbocycles.

摘要

在有机反应中,化学选择性是指一个官能团在另一个官能团存在下的选择性反应活性。如果试剂和反应参数选择得当,这会更成功。一锅法反应已被证明是开发新型杂环或碳环化合物的一种有效的结构多样化技术。这篇综述文章重点介绍了世界各地的研究人员在2013年至2024年期间利用这些方法合成新型有机分子的最新努力以及对其机理的见解。底物、催化剂、溶剂和温度条件对本文所述有机反应中的化学选择性均有重大影响。有机过程中化学选择性的调控为新型杂环和碳环的生产创造了新的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f96/11440482/797f0b2e5e20/d4ra05495d-f1.jpg

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