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临床实践中测量脂蛋白(a)的意义。

The implications of measuring lipoprotein(a) in clinical practice.

作者信息

Barbir Mahmoud, Pottle Alison, Bornstein Stefan R

机构信息

Harefield Hospital, part of Guy's and St Thomas' NHS Foundation Trust, UK.

University Hospital Carl Gustav Carus Dresden, Fetscherstraße 74, 01307 Dresden, Germany.

出版信息

Glob Cardiol Sci Pract. 2024 Aug 1;2024(4):e202440. doi: 10.21542/gcsp.2024.40.

DOI:10.21542/gcsp.2024.40
PMID:39351468
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11439422/
Abstract

Lipoprotein(a) (Lp(a)) is a well-recognized causal risk factor for atherosclerotic cardiovascular disease (ASCVD) and calcific aortic valve stenosis. There are ongoing challenges with screening and management in primary and secondary prevention; however, future recommendations for clinical practice await the outcomes of clinical trials that are in progress.

摘要

脂蛋白(a)(Lp(a))是动脉粥样硬化性心血管疾病(ASCVD)和钙化性主动脉瓣狭窄公认的因果风险因素。在一级和二级预防的筛查和管理方面仍存在挑战;然而,未来临床实践的建议有待正在进行的临床试验结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2103/11439422/d5b89186a3ce/gcsp-2024-4-e202440-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2103/11439422/d5b89186a3ce/gcsp-2024-4-e202440-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2103/11439422/d5b89186a3ce/gcsp-2024-4-e202440-g001.jpg

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本文引用的文献

1
[Correction: State of the art: lipoprotein apheresis].[更正:最新技术水平:脂蛋白分离术]
Dtsch Med Wochenschr. 2023 Apr;148(8):e55. doi: 10.1055/a-2072-6122. Epub 2023 Apr 19.
2
The German Lipoprotein Apheresis Registry-Summary of the ninth annual report.德国脂蛋白分离置换术注册中心——第九年度报告摘要
Ther Apher Dial. 2022 Dec;26 Suppl 1:81-88. doi: 10.1111/1744-9987.13780. Epub 2022 Dec 5.
3
Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease.小干扰 RNA 降低心血管疾病中的脂蛋白(a)。
N Engl J Med. 2022 Nov 17;387(20):1855-1864. doi: 10.1056/NEJMoa2211023. Epub 2022 Nov 6.
4
Increase of serum lipoprotein (a), an adverse effect of growth hormone treatment.生长激素治疗的不良反应:血清脂蛋白(a)升高。
Growth Horm IGF Res. 2022 Dec;67:101503. doi: 10.1016/j.ghir.2022.101503. Epub 2022 Sep 9.
5
Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement.脂蛋白(a)与动脉粥样硬化性心血管疾病及主动脉瓣狭窄:欧洲动脉粥样硬化学会共识声明。
Eur Heart J. 2022 Oct 14;43(39):3925-3946. doi: 10.1093/eurheartj/ehac361.
6
Ancestry, Lipoprotein(a), and Cardiovascular Risk Thresholds: JACC Review Topic of the Week.遗传背景、脂蛋白(a)与心血管风险阈值:JACC 本周综述主题。
J Am Coll Cardiol. 2022 Aug 30;80(9):934-946. doi: 10.1016/j.jacc.2022.06.019.
7
Treatment of Thyroid Dysfunction and Serum Lipids: A Systematic Review and Meta-analysis.甲状腺功能障碍与血脂异常的治疗:系统评价与荟萃分析。
J Clin Endocrinol Metab. 2020 Dec 1;105(12). doi: 10.1210/clinem/dgaa672.
8
Serum lipoprotein(a) levels and insulin resistance have opposite effects on fatty liver disease.血清脂蛋白(a)水平和胰岛素抵抗对脂肪肝疾病有相反的影响。
Atherosclerosis. 2020 Sep;308:1-5. doi: 10.1016/j.atherosclerosis.2020.07.020. Epub 2020 Jul 30.
9
Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function.鉴定和分析针对载脂蛋白(a)kringle 结构域 KIV-7、KIV-10 和 KV 的抑制剂,可深入了解 kringle 结构域的功能。
J Biol Chem. 2020 Apr 10;295(15):5136-5151. doi: 10.1074/jbc.RA119.011251. Epub 2020 Mar 4.
10
Lipoprotein(a) Reduction in Persons with Cardiovascular Disease.脂蛋白(a)降低与心血管疾病患者。
N Engl J Med. 2020 Jan 16;382(3):244-255. doi: 10.1056/NEJMoa1905239. Epub 2020 Jan 1.