细胞间接触会影响细胞对热疗的敏感性。
Cell-cell contact affects cellular sensitivity to hyperthermia.
作者信息
Dobrucki J, Bleehen N M
出版信息
Br J Cancer. 1985 Dec;52(6):849-55. doi: 10.1038/bjc.1985.268.
Abstract
The influence on heat sensitivity of interactions between HT29 human colon adenocarcinoma cells grown in two- or three-dimensional contact was investigated. No evidence for intercellular cooperation affecting cellular sensitivity to hyperthermia was found. Cells grown in monolayer were found to be more heat sensitive than those in aggregates, probably due to the different physical properties of the membrane of flat cells attached to the substratum. Cell-cell contact appears to affect the heat sensitivity of HT29 cells possibly by means of inducing arrest in a heat resistant phase of the cell cycle.
摘要
研究了二维或三维接触培养的HT29人结肠腺癌细胞之间的相互作用对热敏感性的影响。未发现细胞间合作影响细胞对热疗敏感性的证据。发现单层培养的细胞比聚集培养的细胞对热更敏感，这可能是由于附着于基质的扁平细胞的膜具有不同的物理性质。细胞间接触似乎可能通过诱导细胞周期进入耐热期来影响HT29细胞的热敏感性。
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