Dr Rahat Noor, Consultant Radiologist, Cox's Bazar Sadar Hospital, Cox's Bazar, Bangladesh; E-mail:
Mymensingh Med J. 2024 Oct;33(4):1115-1120.
Diabetic nephropathy (DN) is considered the most frequent cause of end-stage renal disease (ESRD). For early diagnosis and follow up of renal function in patient with established DN, Duplex Doppler Sonography can be used as noninvasive tool. The aim and objective of the study was to determine whether resistive index could remain higher in type 2 diabetic patients having nephropathy in comparison with that of non-diabetic controls. This case-control study was done in the department of Radiology and Imaging, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) from 1st Octy 2014 to 30th June 2015. Total 65 diabetic nephropathy patients were taken as study group and 65 healthy subjects were included as healthy control subjects. Duplex Color Doppler sonography of interlobar artery was carried out in both groups for the measurement of Peak systolic velocity, end diastolic velocity and arterial Resistive Index (RI). The RI of interlobar artery of left kidney in control group was 0.58±0.08 (mean±SD) and the mean RI of interlobar artery of left kidney in diabetic nephropathy patients was 0.74±0.53 (mean±SD). The difference of RI of interlobar artery of left kidney in the two groups was statistically significant and the RI of right kidney of control and that of case groups were 0.60±0.09 and 0.76±0.031 (mean±SD) respectively. In between control and case groups the RI of right kidney was statistically significant (p = <0.5). So, resistive index of interlobar artery was increased in type 2 diabetic nephropathy patients in comparison to control group. Study findings reveal that resistive index remains significantly higher in patients with diabetic nephropathy than control group. For this reason, RI can be used for early diagnosis of diabetic nephropathy by Duplex Doppler ultrasonography.
糖尿病肾病（DN）被认为是终末期肾病（ESRD）最常见的原因。对于已确诊的 DN 患者，为了早期诊断和监测肾功能，可以使用双功多普勒超声作为非侵入性工具。本研究的目的是确定患有肾病的 2 型糖尿病患者的阻力指数是否仍高于非糖尿病对照组。本病例对照研究于 2014 年 10 月 1 日至 2015 年 6 月 30 日在孟加拉国糖尿病、内分泌和代谢紊乱研究所的放射科和影像科进行。共纳入 65 例糖尿病肾病患者作为研究组，65 例健康受试者作为健康对照组。对两组患者进行叶间动脉彩色多普勒超声检查，测量收缩期峰值速度、舒张末期速度和动脉阻力指数（RI）。对照组左肾叶间动脉 RI 为 0.58±0.08（均值±标准差），糖尿病肾病患者左肾叶间动脉 RI 均值为 0.74±0.53（均值±标准差）。两组间左肾叶间动脉 RI 差异有统计学意义，对照组和病例组右肾叶间动脉 RI 分别为 0.60±0.09 和 0.76±0.031（均值±标准差）。对照组和病例组右肾 RI 差异有统计学意义（p <0.05）。因此，2 型糖尿病肾病患者的叶间动脉阻力指数较对照组升高。研究结果表明，与对照组相比，糖尿病肾病患者的阻力指数明显升高。因此，RI 可用于双功多普勒超声对糖尿病肾病的早期诊断。
