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体外冲击波治疗对烧伤所致神经损伤和增生性瘢痕患者手部功能恢复的临床效用:一项前瞻性、随机、双盲研究。

Clinical utility of extracorporeal shock wave therapy in restoring hand function of patients with nerve injury and hypertrophic scars due to burns: a prospective, randomized, double-blinded study.

作者信息

Lee Seung Yeol, Cho Yoon Soo, Seo Cheong Hoon, Seo Jisu, Joo So Young

机构信息

Department of Physical Medicine and Rehabilitation, College of Medicine, Soonchunhyang University Hospital, Bucheon, Korea.

Department of Rehabilitation Medicine, Hangang Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.

出版信息

Int J Surg. 2024 Dec 1;110(12):7487-7494. doi: 10.1097/JS9.0000000000002103.

Abstract

BACKGROUND

Joint contractures and nerve injuries are common after hand burns. Extracorporeal shock wave therapy (ESWT) is effective not only for the regeneration of various tissues, including scar tissues, but also for reducing pain and pruritus in patients with burns. Researchers have attempted to explore the effects of ESWT on hand dysfunction caused by nerve injury following burns.

MATERIALS AND METHODS

The authors evaluated the effects of ESWT (compared to sham stimulation) on hands with nerve injury and hypertrophic scars and, thereby, on hand function. The current study was a double-blind randomized controlled trial involving 120 patients. The ESWT parameters were as follows: energy flux density, 0.05-0.30 mJ/mm 2 ; frequency, 4 Hz; 1000-3000 impulses per treatment; and 12 treatments, one/week for 12 weeks. Outcome measures were as follows: 10-point visual analog scale for pain, Jebsen-Taylor hand function test, grip strength, Purdue Pegboard test, ultrasound measurement of scar thickness, and skin characteristics before and immediately after 12 weeks of treatment.

RESULTS

No significant intergroup difference was noted after the initial evaluation ( P >0.05). More significant improvements were found in the ESWT group than in the sham group in terms of the VAS score ( P =0.004), extension ROMs of hand joints ( P =0.02), the JTT scores (writing, small, and light) ( P <0.001, P <0.001, and P =0.002), and skin characteristics (melanin, skin distensibility, and biologic skin elasticity) ( P =0.004, P <0.001, and P <0.001). Other measured outcomes did not differ between the two groups after the treatment.

CONCLUSION

The authors identified the clinically beneficial effects of ESWT in promoting hand function, improving scarring, and alleviating scarring-related pain, thereby highlighting its advantages in improving hand function that has been impaired due to nerve injury and hypertrophic scars after burns.

摘要

背景

手部烧伤后常见关节挛缩和神经损伤。体外冲击波疗法(ESWT)不仅对包括瘢痕组织在内的各种组织的再生有效,而且对减轻烧伤患者的疼痛和瘙痒也有效。研究人员试图探索ESWT对烧伤后神经损伤所致手部功能障碍的影响。

材料与方法

作者评估了ESWT(与假刺激相比)对伴有神经损伤和增生性瘢痕的手部的影响,进而评估其对手部功能的影响。本研究是一项双盲随机对照试验,涉及120例患者。ESWT参数如下:能量通量密度为0.05 - 0.30 mJ/mm²;频率为4 Hz;每次治疗1000 - 3000次脉冲;共治疗12次,每周1次,持续12周。观察指标如下:疼痛的10分视觉模拟量表、Jebsen - Taylor手部功能测试、握力、普渡钉板测试、瘢痕厚度的超声测量以及治疗12周前后的皮肤特征。

结果

初始评估后,两组间无显著差异(P>0.05)。在视觉模拟量表评分(P = 0.004)、手部关节伸展活动度(P = 0.02)、JTT评分(书写、小件物品操作和轻体力操作)(P < 0.001、P < 0.001和P = 0.002)以及皮肤特征(黑色素、皮肤延展性和生物皮肤弹性)(P = 0.004、P < 0.001和P < 0.001)方面,ESWT组比假刺激组有更显著的改善。治疗后两组的其他测量结果无差异。

结论

作者确定了ESWT在促进手部功能、改善瘢痕形成以及减轻瘢痕相关疼痛方面的临床有益效果,从而突出了其在改善因烧伤后神经损伤和增生性瘢痕而受损的手部功能方面的优势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccbe/11634145/acd2c5f29a78/js9-110-7487-g001.jpg

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