Medical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwaizheng Street, Nanchang, 330006, Jiangxi, People's Republic of China.
Queen Mary Academy, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Tissue Eng Regen Med. 2024 Dec;21(8):1109-1124. doi: 10.1007/s13770-024-00669-7. Epub 2024 Oct 1.
Abnormal scarring imposes considerable challenges and burdens on the lives of patients and healthcare system. Macrophages at the wound site are found to be of great concern to overall wound healing. There have been many studies indicating an inextricably link between dysfunctional macrophages and fibrotic scars. Macrophages are not only related to pathogen destruction and phagocytosis of apoptotic cells, but also involved in angiogenesis, keratinization and collagen deposition. These abundant cell functions are attributed to specific heterogeneity and plasticity of macrophages, which also add an extra layer of complexity to correlational researches.
This article summarizes current understanding of macrophage polarization in scar formation and several prevention and treatment strategies on pathological scarring related to regulation of macrophage behaviors by utilizing databases such as PubMed, Google Scholar and so on.
There are many studies proving that macrophages participate in the course of wound healing by converting their predominant phenotype. The potential of macrophages in managing hypertrophic scars and keloid lesions have been underscored.
Macrophage polarization offers new prevention strategies for pathological scarring. Learning about and targeting at macrophages may be helpful in achieving optimum wound healing.
异常瘢痕给患者和医疗系统的生活带来了相当大的挑战和负担。研究发现，伤口部位的巨噬细胞是整体伤口愈合的关键。有许多研究表明，功能失调的巨噬细胞与纤维性瘢痕之间存在着不可分割的联系。巨噬细胞不仅与病原体的破坏和细胞凋亡的吞噬作用有关，还参与血管生成、角化和胶原蛋白的沉积。这些丰富的细胞功能归因于巨噬细胞的特定异质性和可塑性，这也为相关研究增加了额外的复杂性。
本文通过利用 PubMed、Google Scholar 等数据库，总结了目前对巨噬细胞极化在瘢痕形成中的作用的认识，以及几种通过调节巨噬细胞行为来预防和治疗病理性瘢痕的策略。
有许多研究证明巨噬细胞通过转换其主要表型参与伤口愈合过程。巨噬细胞在管理增生性瘢痕和瘢痕疙瘩病变方面的潜力已经得到了强调。
巨噬细胞极化为病理性瘢痕提供了新的预防策略。了解和针对巨噬细胞可能有助于实现最佳的伤口愈合。
