呋塞米诱导的肾前列腺素系统激活的特征

Characterization of furosemide-induced activation of the renal prostaglandin system.

作者信息

Ciabattoni G, Pugliese F, Cinotti G A, Stirati G, Ronci R, Castrucci G, Pierucci A, Patrono C

出版信息

Eur J Pharmacol. 1979 Dec 7;60(2-3):181-7. doi: 10.1016/0014-2999(79)90217-6.

Abstract

A detailed time course of changes in plasma renin activity (PRA), urinary prostaglandin (PG) E2, PGF2 alpha, thromboxane (TX) B2 and sodium excretion rates following furosemide was obtained in 7 women. PRA increased within the first 15 min and remained elevated all through the experiment. PGE2, PGF2 alpha, TXB2 and sodium increased simultaneously, reached a peak between 15 and 45 min after furosemide and declined thereafter. It is concluded that furosemide induces a generalized activation of the renal PG system temporally related to the increase of renin release and natriuresis.

摘要

对7名女性进行了研究，测定了静脉注射速尿后血浆肾素活性（PRA）、尿前列腺素（PG）E2、PGF2α、血栓素（TX）B2及钠排泄率随时间变化的详细过程。PRA在最初15分钟内升高，并在整个实验过程中持续保持升高状态。PGE2、PGF2α、TXB2及钠排泄率同时升高，在速尿注射后15至45分钟之间达到峰值，随后下降。由此得出结论，速尿可诱导肾脏PG系统的全身性激活，且这种激活在时间上与肾素释放及利钠作用的增加相关。