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逆行庆大霉素涂层胫骨髓内钉(ETN PROtect™)治疗距跟舟关节融合术治疗踝关节周围骨缺损:病例系列研究。

Reconstruction of bone defects around the ankle with retrograde gentamicin-coated tibial intramedullary nail (ETN PROtect™) for tibiotalocalcaneal arthrodesis: a case series.

机构信息

Limb of Lengthening and Reconstruction Unit, Clínica Imbanaco Grupo QuirónSalud, Carrera 38A #5ª-100, Tower A, Office 803, Cali, Colombia.

Faculty of Health Sciences, Pontificia Universidad Javeriana Cali, Cali, Colombia.

出版信息

Eur J Orthop Surg Traumatol. 2024 Oct;34(7):3789-3795. doi: 10.1007/s00590-024-04100-8. Epub 2024 Oct 1.

DOI:10.1007/s00590-024-04100-8
PMID:39352525
Abstract

PURPOSE

The objective of this study was to describe the use of retrograde gentamicin-coated tibial intramedullary nail (ETN PROtect™) in patients with tibial defects who required a tibiotalocalcaneal arthrodesis (TTC).

METHODS

Consecutive series case review of seven men treated with TTC using retrograde PROtect™ between January 2018 and December 2023. The main outcomes evaluated were fracture union, complications, and the health-related quality of life using the EuroQol five-dimension three-level questionnaire (EQ-5D-3L).

RESULTS

The mean age was 45.3  8.0 years. Six patients had a clinical history of chronic osteomyelitis, and one case underwent TTC for congenital pseudoarthrosis. Fracture union was achieved in 5 of 7 patients between 4 and 11 months after surgery. Three patients developed complications; two patients had fistulas, and one had persistent pain. At the end of the follow-up, a median of 70 points (interquartile range: 60 to 90) on the EQ-5D-3L was reported. No complications directly attributed to the use of the PROtect™ were reported.

CONCLUSION

TTC with retrograde PROtect™ is a prophylactic treatment option in patients with tibial defects treated with external fixation requiring a tibiotalar and subtalar arthrodesis. This novel use of PROtect™ allows simultaneous fixation of the tibiotalocalcaneal joint and protection of the regenerated bone, facilitating earlier rehabilitation in patients at high risk for postoperative infections.

摘要

目的

本研究旨在描述在需要行胫距跟关节融合术(TTC)的胫骨缺损患者中使用逆行顺行抗生素涂层胫骨髓内钉(ETN PROtect™)的情况。

方法

对 2018 年 1 月至 2023 年 12 月期间使用逆行 PROtect™行 TTC 的 7 例男性患者进行连续系列病例回顾。主要评估的结果包括骨折愈合、并发症和使用欧洲五维健康量表 3 级问卷(EQ-5D-3L)评估的健康相关生活质量。

结果

平均年龄为 45.3 ± 8.0 岁。6 例患者有慢性骨髓炎的临床病史,1 例患者因先天性假关节行 TTC。5 例患者在术后 4 至 11 个月实现骨折愈合。3 例患者出现并发症;2 例患者有瘘管,1 例患者有持续性疼痛。在随访结束时,EQ-5D-3L 的中位数为 70 分(四分位距:60 至 90)。未报告与 PROtect™使用直接相关的并发症。

结论

对于需要行外固定架固定且需要行胫距和距下关节融合术的胫骨缺损患者,逆行 PROtect™TTC 是一种预防性治疗选择。PROtect™的这种新用途可同时固定胫距跟关节并保护再生骨,便于对术后感染风险高的患者进行早期康复。

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本文引用的文献

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The outcomes of the management of complex distal tibia and ankle fractures in elderly with tibiotalocalcaneal nail in a minimum 12-month follow-up period.在至少 12 个月的随访期内,使用跟距骨钉治疗老年复杂胫骨远端和踝关节骨折的治疗结果。
Eur J Orthop Surg Traumatol. 2024 Jul;34(5):2723-2728. doi: 10.1007/s00590-024-03970-2. Epub 2024 May 18.
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Open fractures: evidence-based best practices.开放性骨折:基于证据的最佳实践。
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Is fracture management merely a physical process? Exploring the psychological effects of internal and external fixation.
骨折管理仅仅是一个物理过程吗?探究内固定和外固定的心理影响。
J Orthop Surg Res. 2024 Apr 8;19(1):231. doi: 10.1186/s13018-024-04655-6.
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Predictors for infection severity for open tibial fractures: major trauma centre perspective.开放性胫骨骨折感染严重程度的预测因素:大型创伤中心视角。
Arch Orthop Trauma Surg. 2023 Nov;143(11):6579-6587. doi: 10.1007/s00402-023-04956-1. Epub 2023 Jul 7.
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Tibiotalocalcaneal Arthrodesis in Severe Hindfoot Deformities.三关节融合术治疗严重后足畸形。
Foot Ankle Clin. 2022 Dec;27(4):847-866. doi: 10.1016/j.fcl.2022.08.008.
6
Functional and radiological outcomes of primary ring fixator versus antibiotic nail in open tibial diaphyseal fractures: A prospective study.一期环形外固定架与抗生素骨水泥髓内钉治疗开放性胫骨骨干骨折的功能和影像学结果:一项前瞻性研究。
Injury. 2022 Oct;53(10):3464-3470. doi: 10.1016/j.injury.2022.08.020. Epub 2022 Aug 9.
7
A major trauma centre experience with gentamicin-coated tibial intramedullary nails (ETN PROtect™) in acute primary open fracture fixation and complex revision surgery.一家大型创伤中心在急性原发性开放性骨折固定和复杂翻修手术中使用氨基糖苷类抗生素涂层胫骨髓内钉(ETN PROtect™)的经验。
Eur J Orthop Surg Traumatol. 2023 Jul;33(5):1745-1750. doi: 10.1007/s00590-022-03338-4. Epub 2022 Aug 9.
8
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J Bone Jt Infect. 2020 May 29;5(4):176-183. doi: 10.7150/jbji.46570. eCollection 2020.
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