兔脑中血管紧张素II和III的结合与致渴性

Brain angiotensin II and III binding and dipsogenicity in the rabbit.

作者信息

Wright J W, Sullivan M J, Petersen E P, Harding J W

出版信息

Brain Res. 1985 Dec 9;358(1-2):376-9. doi: 10.1016/0006-8993(85)90988-6.

Abstract

The rabbit brain evidenced low or non-detectable levels of [125I]angiotensin II binding but considerable [125I]angiotensin III specific binding in agreement with distributions reported for the primate brain. The rabbit was dispsogenically responsive to the intracerebroventricular infusions of angiotensin II and III; however, no elevations in blood pressure were measured for either peptide. Thus, members of this species appear to have limited usefulness as a primate model for central angiotensin-induced cardiovascular changes.

摘要

兔脑显示出低水平或无法检测到的[125I]血管紧张素II结合，但有相当数量的[125I]血管紧张素III特异性结合，这与灵长类动物脑的分布报道一致。兔对脑室内注入血管紧张素II和III有饮水反应；然而，两种肽均未测得血压升高。因此，作为中枢血管紧张素诱导的心血管变化的灵长类动物模型，该物种的成员似乎用途有限。