Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Department of Human Physiology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Endocr Regul. 2024 Oct 1;58(1):187-194. doi: 10.2478/enr-2024-0022. Print 2024 Jan 1.
Studies that have evaluated correlation between body mass index (BMI) and novel lipid indices such as triglycerides (TG)/high-density lipoprotein-cholesterol (HDL-C), total cholesterol (TC)/HDL-C, and low-density lipoprotein cholesterol (LDL-C)/HDL-C in type 2 diabetes mellitus (T2DM) are scarce. Hence, the aim of the present study was to explore the correlation between BMI and novel lipid indices in Bosnian patients with T2DM. Present study included 117 patients with T2DM (mean age: 66.51 years) and 68 controls (mean age: 68.37 years). BMI was calculated as weight/height². Lipids were measured by standard methods. TG/HDL-C, TC/HDL-C, and LDL-C/HDL-C ratios were separately calculated. The differences between the groups were assessed by Student's t-test or Man Whitney U test. Correlations were determined by Spearman's test. In a total sample of T2DM patients, 41.0% were overweight and 44.4% were obese. In the control group, 51.5% of subjects were overweight and 25.0% were obese. In T2DM group, a significant correlation was observed between BMI and HDL-C, LDL-C, TG/HDL, TC/HDL-C, and LDL-C/HDL-C ratios. In the control group, there was a significant correlation found between BMI and HDL-C, TG, TG/HDL, TC/HDL-C, and LDL-C/HDL-C-ratios. Correlation between BMI and other lipid parameters in T2DM and the control group was not determined. The present study showed significant correlation between BMI and novel lipid indices in both T2DM patients and the control group of subjects. Possible explanation for the observed results might be prevalence of overweight and obese participants in this study sample. Since novel lipid indices are used in the prediction of cardiometabolic risk, results obtained in the present study have valuable clinical implications.
在 2 型糖尿病（T2DM）患者中，评估体重指数（BMI）与新型血脂指标（如甘油三酯（TG）/高密度脂蛋白胆固醇（HDL-C）、总胆固醇（TC）/HDL-C 和低密度脂蛋白胆固醇（LDL-C）/HDL-C）之间相关性的研究较少。因此，本研究旨在探讨波斯尼亚 T2DM 患者 BMI 与新型血脂指标之间的相关性。本研究纳入了 117 例 T2DM 患者（平均年龄：66.51 岁）和 68 例对照者（平均年龄：68.37 岁）。BMI 通过体重/身高²计算。脂质采用标准方法测量。分别计算 TG/HDL-C、TC/HDL-C 和 LDL-C/HDL-C 比值。两组间差异采用 Student's t 检验或 Man Whitney U 检验评估。相关性采用 Spearman 检验确定。在 T2DM 患者的总样本中，41.0%为超重，44.4%为肥胖。在对照组中，51.5%的受试者超重，25.0%肥胖。在 T2DM 组中，BMI 与 HDL-C、LDL-C、TG/HDL、TC/HDL-C 和 LDL-C/HDL-C 比值呈显著相关。在对照组中，BMI 与 HDL-C、TG、TG/HDL、TC/HDL-C 和 LDL-C/HDL-C 比值呈显著相关。T2DM 组和对照组 BMI 与其他血脂参数之间的相关性未确定。本研究显示，T2DM 患者和对照组受试者 BMI 与新型血脂指标之间存在显著相关性。观察结果可能是由于研究样本中超重和肥胖参与者的患病率较高。由于新型血脂指标用于预测心血管代谢风险，因此本研究结果具有重要的临床意义。
