Hsieh Yi-Ying, Chien Shuo-Chi, Tsai Hong-Chieh, Wei Kuo-Chen, Chuang Chi-Cheng, Jung Shih-Ming
Department of Neurosurgery, Chang Gung Memorial Hospital, Linkou Center, Taoyuan City, Taiwan.
Department of Neurosurgery, Chang Gung Memorial Hospital, Linkou Center, Taoyuan City, Taiwan.
Int J Surg Case Rep. 2024 Nov;124:110328. doi: 10.1016/j.ijscr.2024.110328. Epub 2024 Sep 21.
Pituitary spindle cell oncocytoma (PSCO) is a seldom-encountered type of pituitary neoplasm with distinctive histological features. It was first described as a distinct entity by Roncaroli et al. in 2002. We present two cases of PSCO and discuss its clinical, radiological, and histopathological features, along with a review of the existing literature.
Two cases underwent trans-nasal transsphenoidal surgery for tumor resection and had different treatment following would be discussed in this article. Both had unique pathology pattern as Pituitary spindle cell oncocytoma.
Tumors positive for TTF-1 in the sellar region, such as pituicytoma, granular cell tumor, and spindle cell oncocytoma, originate from the posterior pituitary gland and are rare. The expression of thyroid transcription factor-1 (TTF-1) in these tumors aids in distinguishing them from other pituitary neoplasms.
Pituitary spindle cell oncocytoma is a rare entity among pituitary tumors. This case report highlights the clinical, radiological, histopathological, and immunohistochemical features of PSCO. Surgeons and pathologists should consider this rare diagnosis in patients with sellar and suprasellar masses, as early recognition and complete surgical resection can lead to favorable outcomes.
垂体梭形细胞嗜酸细胞瘤（PSCO）是一种罕见的垂体肿瘤类型，具有独特的组织学特征。它于2002年被龙卡罗利等人首次描述为一种独特的实体。我们报告两例PSCO病例，并讨论其临床、放射学和组织病理学特征，同时回顾现有文献。
两例患者均接受了经鼻蝶窦手术以切除肿瘤，术后接受了不同的治疗，本文将对此进行讨论。两例均具有垂体梭形细胞嗜酸细胞瘤独特的病理模式。
鞍区中甲状腺转录因子-1（TTF-1）阳性的肿瘤，如垂体细胞瘤、颗粒细胞瘤和梭形细胞嗜酸细胞瘤，起源于垂体后叶，较为罕见。这些肿瘤中甲状腺转录因子-1（TTF-1）的表达有助于将它们与其他垂体肿瘤区分开来。
垂体梭形细胞嗜酸细胞瘤在垂体肿瘤中是一种罕见的实体。本病例报告突出了PSCO的临床、放射学、组织病理学和免疫组化特征。对于鞍区和鞍上肿块患者，外科医生和病理学家应考虑这种罕见的诊断，因为早期识别和完整的手术切除可带来良好的结果。
