El Hussein Siba, Vincentelli Cristina
Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Suite 2400, Alton Road 4300, Miami Beach, 33140, FL,USA.
Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Suite 2400, Alton Road 4300, Miami Beach, 33140, FL,USA.
Ann Diagn Pathol. 2017 Aug;29:57-61. doi: 10.1016/j.anndiagpath.2017.05.004. Epub 2017 May 11.
Pituicytoma is a rare low-grade glial neoplasm that originates in the distribution of the neurohypophysis, including the posterior pituitary lobe and infundibular stalk. The tumor cells resemble pituicytes, which are specialized glial cells of the neurohypophysis. Pituicytoma can be misdiagnosed pre-operatively as a pituitary adenoma due to overlapping clinical and neuroimaging features between these two entities. Pituicytoma can also mimic other neoplasms of the sellar and parasellar regions microscopically - meningioma, schwannoma and pilocytic astrocytoma - and shares immunohistochemical expression of TTF-1 with spindle cell oncocytoma and granular cell tumor of the sellar region, suggesting a common histogenesis. In this short review, we present the key features of pituicytoma, discuss commonalities and distinguishing features from other neoplasms of the sellar and parasellar regions and highlight the importance of recognizing this tumor entity for clinical and surgical management.
垂体细胞瘤是一种罕见的低级别神经胶质瘤，起源于神经垂体的分布区域，包括垂体后叶和漏斗柄。肿瘤细胞类似于垂体细胞，垂体细胞是神经垂体的特殊神经胶质细胞。由于垂体细胞瘤与垂体腺瘤在临床和神经影像学特征上存在重叠，术前可能会被误诊为垂体腺瘤。垂体细胞瘤在显微镜下也可能与鞍区和鞍旁区域的其他肿瘤相似——脑膜瘤、神经鞘瘤和毛细胞型星形细胞瘤——并且与鞍区的梭形细胞嗜酸细胞瘤和颗粒细胞瘤共享甲状腺转录因子-1（TTF-1）的免疫组化表达，提示共同的组织发生学。在这篇简短的综述中，我们介绍了垂体细胞瘤的关键特征，讨论了与鞍区和鞍旁区域其他肿瘤的共性和鉴别特征，并强调了识别这种肿瘤实体对于临床和手术管理的重要性。
