Peadiatrics, Scarborough General Hospital, Scarborough, North Yorkshire, UK
Peadiatrics, Scarborough General Hospital, Scarborough, North Yorkshire, UK.
BMJ Case Rep. 2024 Oct 1;17(10):e262467. doi: 10.1136/bcr-2024-262467.
We present a case of a girl in her early childhood with a background of chromosomal deletion 10q21.2, hypothyroidism, second-degree atrioventricular block, developmental delay, gastroesophageal reflux disease, constipation and recurrent fevers. She had subcutaneous nodules, which represented panniculitis. Diagnosis of fever of unknown origin (FUO) associated with panniculitis was very challenging despite the involvement of geneticist, dermatologist, rheumatologist and paediatrician. To detect possible malignant cases and start treatment plans promptly, the case emphasises the need for a comprehensive diagnostic examination, which includes an early biopsy of nodular lesions. To maximise patient outcomes in complicated paediatric presentations, it emphasises the need for continual multidisciplinary teamwork and close monitoring. This case adds to the body of knowledge on the treatment of panniculitis and FUO in paediatric patients, highlighting the need of a comprehensive approach to treatment.
我们报告了一例患有染色体缺失 10q21.2、甲状腺功能减退、二度房室传导阻滞、发育迟缓、胃食管反流病、便秘和反复发热的幼儿病例。她有皮下结节，代表脂膜炎。尽管涉及遗传学家、皮肤科医生、风湿病学家和儿科医生，但诊断与脂膜炎相关的不明原因发热（FUO）仍然极具挑战性。为了及时发现可能的恶性病例并开始治疗计划，该病例强调需要进行全面的诊断检查，包括结节性病变的早期活检。为了最大限度地提高复杂儿科表现患者的治疗效果，需要不断的多学科团队合作和密切监测。该病例增加了儿童脂膜炎和 FUO 治疗方面的知识体系，强调了综合治疗方法的必要性。
