Velumula Pradeep Kumar, Boddu Praveen Kumar, Khanal Luna, Jani Sanket, Fernandes Nithi, Thomas Ronald, Bajaj Monika, Chawla Sanjay
MercyOne Waterloo Medical Center, Waterloo, IA, 50702, USA.
Hutzel Women's Hospital, Detroit Medical Center, Detroit, MI, 48201, USA.
J Perinatol. 2025 Jan;45(1):24-29. doi: 10.1038/s41372-024-02130-y. Epub 2024 Oct 1.
There is limited evidence on the efficacy of antenatal steroids (ANS) among women with multiple gestations at risk of late preterm delivery.
This retrospective study included multiple gestation, late preterm infants (34-36 weeks' gestational age), born between January 2013 and December 2022. The primary outcome was composite respiratory outcome, defined as the need for respiratory support by 72 hours of age. Logistic and linear regressions were performed to compare the primary and secondary outcomes with and without exposure to any ANS, adjusted for gestational age, sex of infant, histologic chorioamnionitis, and intrauterine growth restriction.
The composite respiratory outcome was significantly lower in any ANS group compared to no ANS group (28.6% vs. 33.7%) [adjusted odds ratio 0.50, 95% CI, 0.33-0.75, p < 0.001].
In late preterm multiple gestation infants, any ANS exposure was associated with lower risk of composite respiratory outcome.
关于产前类固醇（ANS）对有晚期早产风险的多胎妊娠女性的疗效证据有限。
这项回顾性研究纳入了2013年1月至2022年12月期间出生的多胎、晚期早产婴儿（胎龄34 - 36周）。主要结局是复合呼吸结局，定义为出生后72小时内需呼吸支持。进行逻辑回归和线性回归，以比较暴露于任何产前类固醇和未暴露于产前类固醇的主要和次要结局，并对胎龄、婴儿性别、组织学绒毛膜羊膜炎和宫内生长受限进行了校正。
与未使用产前类固醇组相比，使用产前类固醇组的复合呼吸结局显著更低（28.6%对33.7%）[校正比值比0.50，95%置信区间，0.33 - 0.75，p < 0.001]。
在晚期早产多胎妊娠婴儿中，任何产前类固醇暴露均与复合呼吸结局风险降低相关。
