Qiao Haizhou, Li Siqi, Xu Yanfeng, Wang Wei, Yang Jigang
From the Department of Nuclear Medicine, Beijing RIMAG Medical Imaging Center, Beijing, China.
Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing, China.
Clin Nucl Med. 2025 Jan 1;50(1):91-93. doi: 10.1097/RLU.0000000000005448. Epub 2024 Oct 2.
Contrast enhancement MRI of the brain and spine showed abnormal enhancement in intracranial and spinal dural lesions in a 6-year-old boy with high-risk neuroblastoma, suggesting the possibility of dural metastases. 123 I-MIBG SPECT/CT did not show any abnormal MIBG accumulation in these lesions. However, 68 Ga-DOTATATE PET/CT showed obvious DOTATATE uptake in these metastatic lesions. Surgical pathology confirmed the diagnosis of intracranial dural metastasis. Concurrent intracranial and spinal dural metastases from neuroblastoma demonstrated by 68 Ga-DOTATATE PET/CT with negative 123 I-MIBG SPECT/CT have not been reported previously.
一名患有高危神经母细胞瘤的6岁男孩的脑部和脊柱对比增强磁共振成像显示颅内和脊髓硬脑膜病变有异常强化，提示存在硬脑膜转移的可能性。123I-MIBG单光子发射计算机断层扫描/计算机断层扫描未显示这些病变中有任何异常的MIBG聚集。然而，68Ga- DOTATATE正电子发射断层扫描/计算机断层扫描显示这些转移病变中有明显的DOTATATE摄取。手术病理证实为颅内硬脑膜转移。68Ga- DOTATATE正电子发射断层扫描/计算机断层扫描显示而123I-MIBG单光子发射计算机断层扫描/计算机断层扫描阴性的神经母细胞瘤并发颅内和脊髓硬脑膜转移此前未见报道。
