[淋病奈瑟菌菌型分类在评估淋病治疗研究中的重要性]
[Importance of the auxotyping of Neisseria gonorrhoeae for evaluating gonorrhea therapy studies].
作者信息
Korting H C, Abeck D, Neubert U
出版信息
Dermatologica. 1985;171(3):175-9.
PMID:3935493
Abstract
So far, there was no absolutely reliable way to distinguish between failure and reinfection in clinical trials on the treatment of gonorrhoea. If one, however, analyzes the auxotypes of the gonococcal strains isolated before and after application of the drug from non-cured patients, reinfection can clearly be demonstrated in cases with a changed auxotype. Thus, in a trial on the single intramuscular application of cefotiam 1 g for uncomplicated gonorrhoea, the bacteriological cure rate increased from 90 to at least 95%.
摘要
到目前为止，在淋病治疗的临床试验中，尚无绝对可靠的方法来区分治疗失败和再次感染。然而，如果分析未治愈患者用药前后分离出的淋球菌菌株的菌型，在菌型发生变化的病例中可以明确证明存在再次感染。因此，在一项针对单纯性淋病单次肌内注射1g头孢替安的试验中，细菌学治愈率从90%提高到了至少95%。
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