Mu Xingyu, Huang Xiaoxue, Li Meng, Sun Wenjie, Fu Wei
Department of Nuclear Medicine, Affiliated Hospital, Guilin Medical University, Guilin, China.
Front Nucl Med. 2022 Sep 29;2:927843. doi: 10.3389/fnume.2022.927843. eCollection 2022.
To calculate the physiological uptake of various tissues in patients with cancer using F-AlF-NOTA-FAPI-04 (F-FAPI-04) and F-AlF-NOTA-FAPI-42 (F-FAPI-42) PET/CT and to compare the variation in standard uptake values between the two scans.
This retrospective analysis included 40 patients with cancer who underwent F-FAPI; the first 20 patients received F-FAPI-04 PET/CT and the remaining 20 patients received F-FAPI-42 PET/CT. A total of 49 normal tissues, including the brain (cerebrum/cerebellum), parotid and submandibular glands, palatine tonsils, and thyroid, were identified on CT images. For these normal tissues, maximum standardized uptake value (SUVmax) and mean standardized uptake value (SUVmean) were calculated. We also compared the SUVmean of identical tissues to explore the difference in biodistribution between the two radiotracers.
The accumulation of F-FAPI-04 and F-FAPI-42 showed an analogous pattern. High uptake of both radiotracers in the gallbladder, uterus, submandibular gland, and renal pelvis was demonstrated (range: SUVmax, 4.01-5.75; SUVmean, 2.92-4.22). Furthermore, the uptake of bony tissues was slightly higher in F-FAPI-42 than in F-FAPI-04 (range: SUVmean, 0.4 ± 0.22-0.9 ± 0.34 and 0.3 ± 0.24-0.7 ± 0.18, respectively, < 0.05), while the uptake of some soft tissues was higher in F-FAPI-04 than in F-FAPI-42 (range: SUVmean, 0.9 ± 0.24-1.5 ± 0.35 and 0.9 ± 0.26-1.2 ± 0.37, respectively, < 0.05).
Both radioligands exhibited similar physiological uptake of normal tissues in patients with cancers. In addition, F-FAPI-42 demonstrated higher uptake of bone tissues than F-FAPI-04 while showing lower uptake of soft tissues than F-FAPI-04.
使用F-AlF-NOTA-FAPI-04（F-FAPI-04）和F-AlF-NOTA-FAPI-42（F-FAPI-42）PET/CT计算癌症患者各种组织的生理摄取量，并比较两次扫描之间标准摄取值的变化。
这项回顾性分析纳入了40例接受F-FAPI检查的癌症患者；前20例患者接受F-FAPI-04 PET/CT检查，其余20例患者接受F-FAPI-42 PET/CT检查。在CT图像上共识别出49个正常组织，包括脑（大脑/小脑）、腮腺和颌下腺、腭扁桃体和甲状腺。对于这些正常组织，计算最大标准化摄取值（SUVmax）和平均标准化摄取值（SUVmean）。我们还比较了相同组织的SUVmean，以探讨两种放射性示踪剂在生物分布上的差异。
F-FAPI-04和F-FAPI-42的摄取表现出相似的模式。两种放射性示踪剂在胆囊、子宫、颌下腺和肾盂中均表现出高摄取（范围：SUVmax，4.01 - 5.75；SUVmean，2.92 - 4.22）。此外，F-FAPI-42对骨组织的摄取略高于F-FAPI-04（范围：SUVmean分别为0.4±0.22 - 0.9±0.34和0.3±0.24 - 0.7±0.18，P<0.05），而F-FAPI-04对一些软组织的摄取高于F-FAPI-42（范围：SUVmean分别为0.9±0.24 - 1.5±0.35和0.9±0.26 - 1.2±0.37，P<0.05）。
两种放射性配体在癌症患者的正常组织中均表现出相似的生理摄取。此外，F-FAPI-42对骨组织的摄取高于F-FAPI-04，而对软组织的摄取低于F-FAPI-04。
