Sakano Yuta, Okumura Taro, Kofuku Tomomi, Kidaka Saki, Nakata Yugo, Katsura Satoshi, Goto Kenichi, Shigematsu Michio
Department of Pulmonology, Sumitomo Hospital, Osaka, JPN.
Department of Clinical Laboratory Technology, Sumitomo Hospital, Osaka, JPN.
Cureus. 2024 Sep 1;16(9):e68366. doi: 10.7759/cureus.68366. eCollection 2024 Sep.
A female patient in her thirties presented with persistent cough and sputum, unresponsive to conventional treatments. Chest imaging showed infiltrative opacities and high attenuation mucus. On laboratory examination, eosinophil counts and immunoglobulin E were elevated. ,a species of caterpillar fungi, was identified by bronchoscopy and subsequent DNA sequencing from the mucus plug. The symptoms improved after the removal of mucus plugs and cessation of exposure to the work environment. Allergic bronchopulmonary mycosis (ABPM) caused by has not been reported, and its pathogenicity is not well recognized. Herein, we report this case to understand the disease spectrum of ABPM and the pathogenicity of this rare fungi.
一名三十多岁的女性患者出现持续咳嗽和咳痰症状,常规治疗无效。胸部影像学显示浸润性混浊和高衰减黏液。实验室检查显示嗜酸性粒细胞计数和免疫球蛋白E升高。通过支气管镜检查及随后从黏液栓进行的DNA测序,鉴定出黏液栓中有冬虫夏草菌。清除黏液栓并停止接触工作环境后,症状有所改善。由冬虫夏草菌引起的变应性支气管肺真菌病(ABPM)尚未见报道,其致病性也未得到充分认识。在此,我们报告该病例以了解ABPM的疾病谱及这种罕见真菌的致病性。