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外泌体是肿瘤微环境与前列腺癌之间的介质(综述)。

Exosomes are the mediators between the tumor microenvironment and prostate cancer (Review).

作者信息

Wu Yiqi, Wang Xiao, Zeng Yan, Liu Xiuheng

机构信息

Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

出版信息

Exp Ther Med. 2024 Sep 25;28(6):439. doi: 10.3892/etm.2024.12728. eCollection 2024 Dec.

Abstract

Prostate cancer poses a serious threat to the well-being of men worldwide, with the leading cause of mortality being primarily through metastasis. Prostate cancer metastasis is dependent on cell communication, which is an essential component of this process; yet its exact mechanism remains obscure. Nonetheless, cell-to-cell communication plays a critical part in prostate cancer metastasis. Exosomes play an indispensable role in the development of metastatic growth by promoting intercellular communication. They are pivotal regulatory agents for both prostate cancer cells as well as their microenvironment. The present study investigated the makeup and function of exosomes in the tumor microenvironment, highlighting their significance to prostate cancer metastasis.

摘要

前列腺癌对全球男性的健康构成严重威胁,其主要死亡原因主要是转移。前列腺癌转移依赖于细胞通讯,这是该过程的一个重要组成部分;但其确切机制仍不清楚。尽管如此,细胞间通讯在前列腺癌转移中起着关键作用。外泌体通过促进细胞间通讯在转移性生长的发展中发挥不可或缺的作用。它们是前列腺癌细胞及其微环境的关键调节因子。本研究调查了肿瘤微环境中外泌体的组成和功能,强调了它们对前列腺癌转移的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72bf/11443591/c02d34e83fa3/etm-28-06-12728-g00.jpg

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