Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA.
Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA.
Dev Cell. 2019 May 6;49(3):347-360. doi: 10.1016/j.devcel.2019.04.011.
Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell communication via extracellular vesicles (exosomes and microvesicles) between primary tumor cells and the microenvironment of distant organs is crucial for pre-metastatic niche (PMN) formation and metastasis. Here, we review work on the contribution of exosome cargo to cancer progression, the role of exosomes in PMN establishment, and the function of exosomes in organotropic metastasis. We also describe the clinical utility of exosomes.
转移是肿瘤进展的关键阶段，仍然是癌症治疗的主要挑战，也是癌症死亡的主要原因。原发肿瘤细胞与远处器官微环境之间通过细胞外囊泡（外泌体和微囊泡）的细胞间通讯对于前转移灶（PMN）的形成和转移至关重要。在这里，我们回顾了外泌体货物对癌症进展的贡献、外泌体在PMN 建立中的作用以及外泌体在器官趋向性转移中的功能。我们还描述了外泌体的临床应用。
