Xian Shenglin, Zeng Zhiyu
Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, Guangxi, China.
Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, 530021 Nanning, Guangxi, China.
Rev Cardiovasc Med. 2024 Sep 24;25(9):346. doi: 10.31083/j.rcm2509346. eCollection 2024 Sep.
Rheumatic heart disease (RHD) is responsible for nearly 250,000 deaths annually and poses a significant health threat in developing areas. The unclear pathogenesis of RHD makes the development of cost-effective treatments challenging, particularly as current surgical options are expensive and technologically demanding, exacerbating the economic and quality-of-life burdens for patients. Given the risks associated with direct human experimentation due to the uncertain pathogenesis, using a rat model infected with Group A Streptococcus (GAS) has become a crucial experimental strategy for RHD research. The development of an RHD rat model, refined over 23 years, now stands as a pivotal approach in studies aiming to understand the disease's pathogenesis. This review summarizes the evolution, characteristics, advantages, and limitations of the RHD rat model, offering insights into potential areas for improvement. It aims to provide researchers with a comprehensive understanding of the model, supporting the advancement of research methodologies and the discovery of innovative treatments for RHD.
风湿性心脏病（RHD）每年导致近25万人死亡，对发展中地区的健康构成重大威胁。RHD发病机制不明，使得开发具有成本效益的治疗方法具有挑战性，特别是因为目前的手术选择昂贵且技术要求高，加剧了患者的经济负担和生活质量负担。鉴于由于发病机制不确定而进行直接人体实验存在风险，使用感染A组链球菌（GAS）的大鼠模型已成为RHD研究的关键实验策略。经过23年完善的RHD大鼠模型的开发，如今已成为旨在了解该疾病发病机制的研究中的关键方法。本综述总结了RHD大鼠模型的演变、特征、优点和局限性，为潜在的改进领域提供见解。其目的是为研究人员提供对该模型的全面理解，支持研究方法的进步以及RHD创新治疗方法的发现。
