Xian Shenglin, Zeng Zhiyu
Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Disease Control and Prevention and Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
Exp Ther Med. 2021 Jan;21(1):76. doi: 10.3892/etm.2020.9508. Epub 2020 Nov 25.
Rheumatic heart disease (RHD) is frequently encountered in underdeveloped areas and primarily affects patients under the age of 40 years old. The pathogenesis of RHD has yet to be fully elucidated and surgical treatment remains the only option, which is expensive and technically demanding for patients in less developed areas. Signalling pathways are crucial for the occurrence and development of several diseases, and researchers worldwide have made progress in elucidating the signalling pathways associated with the pathogenesis of RHD. The aim of the present review was to discuss 6 signalling pathways implicated in the pathogenesis of RHD, summarize the methods and progress of these studies and propose future research directions. Important information on the pathogenesis of RHD according to the current progress of signalling pathway studies was also summarized, in the hope that this review may serve as a reference for future research on the signalling pathways involved in the pathogenesis of RHD.
风湿性心脏病（RHD）在欠发达地区屡见不鲜，主要影响40岁以下的患者。RHD的发病机制尚未完全阐明，手术治疗仍然是唯一的选择，而这对欠发达地区的患者来说费用高昂且技术要求高。信号通路对多种疾病的发生和发展至关重要，世界各地的研究人员在阐明与RHD发病机制相关的信号通路上取得了进展。本综述的目的是讨论与RHD发病机制相关的6条信号通路，总结这些研究的方法和进展，并提出未来的研究方向。还根据信号通路研究的当前进展总结了RHD发病机制的重要信息，希望本综述可为未来RHD发病机制相关信号通路的研究提供参考。
