Alhetheli Ghadah
Department of Dermatology and Cutaneous Surgery, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
Pan Afr Med J. 2024 Jun 27;48:70. doi: 10.11604/pamj.2024.48.70.44097. eCollection 2024.
Basal cell carcinoma (BCC) is a low-grade malignant tumor that if properly managed has an excellent prognosis. Development of BCC outside the skin areas exposed to sun rays is infrequent. Giant BCC is a rare entity, especially in unexposed areas of the body. It carries a considerable implication on patients' quality of life because of the risk of being a source of infection that may progress to severe sepsis and/or metastasis. An old female presented with a long-standing solitary lesion measuring 7.5x6 cm overlaying the lumber 4-5 vertebral region about 2.5 cm from the line of the sacral promontory. No lymph nodes or distant metastases were detected. For many years, it was misdiagnosed by other physicians as eczema, psoriasis, and fungal infection and accordingly failed to respond to treatment. A histopathological examination of lesional punch biopsy assured the diagnosis of giant superficially spreading BCC. The lesion was excised with a circumferential safety margin of about 5 mm. During the follow-up period of 4 years, no recurrence was detected. Despite being a long-standing Giant basal cell carcinoma (GBCC) in a sun-hidden skin area, the growth behaved as a locally malignant lesion without metastasizing. A wide local surgical excision of the GBCC with 5 mm safety margins was feasible, safe, and with a good aesthetic outcome. Importantly, family practitioners should avoid such missed cases through accuracy in their diagnosis and early referral of any atypical cases to a dermatologist.
基底细胞癌(BCC)是一种低级别恶性肿瘤,若得到妥善处理,预后良好。在未暴露于阳光的皮肤区域发生BCC的情况并不常见。巨大基底细胞癌是一种罕见的病症,尤其是在身体未暴露部位。由于存在感染风险,可能进展为严重脓毒症和/或转移,这对患者的生活质量有相当大的影响。一名老年女性患者,在第4 - 5腰椎区域距骶岬连线约2.5厘米处有一个长期存在的孤立性病灶,大小为7.5×6厘米。未检测到淋巴结或远处转移。多年来,其他医生一直将其误诊为湿疹、银屑病和真菌感染,因此治疗无效。对病灶进行打孔活检的组织病理学检查确诊为巨大浅表扩散型BCC。该病灶以约5毫米的周缘安全切缘切除。在4年的随访期内,未检测到复发。尽管这是一个位于阳光照射不到的皮肤区域的长期巨大基底细胞癌(GBCC),但其生长表现为局部恶性病变,未发生转移。对GBCC进行带5毫米安全切缘的广泛局部手术切除是可行、安全的,且美容效果良好。重要的是,家庭医生应通过准确诊断并将任何非典型病例尽早转诊给皮肤科医生,避免出现此类漏诊情况。