Forensic Science SA, The University of Adelaide, Australia.
Adelaide Medical School, The University of Adelaide, Australia.
Med Sci Law. 2022 Jan;62(1):70-73. doi: 10.1177/00258024211041792. Epub 2021 Sep 3.
Basal cell carcinomas are the most common malignancy in Caucasian populations with a very low predisposition to metastatic disease and an excellent prognosis if appropriately treated. Given the rarity of a lethal outcome two cases are reported. : A 61-year-old reclusive man who had an untreated facial basal cell carcinoma for 10 years died of hypothermia and sepsis complicating the extensively ulcerated and infected tumour. He also had underlying cardiomegaly, ischaemic heart disease and chronic obstructive pulmonary disease. : A 60-year-old man who had an untreated lower lumbar basal cell carcinoma for 14 years died of sepsis, inanition and pulmonary thromboembolism (due to a right-sided deep venous thrombosis) complicating the deeply ulcerated tumour. Untreated giant basal cell carcinoma may uncommonly present for medicolegal assessment with complex pathophysiological lethal mechanisms. The possibility of Diogenes syndrome should be considered.
基底细胞癌是白种人群中最常见的恶性肿瘤，其转移性疾病的易感性非常低，如果得到适当治疗，预后良好。鉴于致命结果的罕见性，报告了两例病例。
一名 61 岁的孤僻男子，面部基底细胞癌未经治疗已达 10 年，因广泛溃疡和感染的肿瘤并发的低温症和败血症而死亡。他还患有心脏肥大、缺血性心脏病和慢性阻塞性肺疾病。
一名 60 岁男子，未经治疗的下腰椎基底细胞癌已达 14 年，因严重溃疡肿瘤并发的败血症、消瘦和肺血栓栓塞症（由于右侧深静脉血栓形成）而死亡。未经治疗的巨大基底细胞癌可能罕见地出现医学法律评估，并伴有复杂的病理生理学致死机制。应考虑到狄俄尼索斯综合征的可能性。
