Hussein Al-Janabi Moatasem, Diab Sdrah, Aljammal Ghina, Kassab Lina, Al-Shehabi Zuheir, Al-Soiufi Lina
Department of Pathology Cancer Research Center Tishreen University Hospital Lattakia Syria.
Department of Dermatology and Sexually Transmitted Disease Tishreen University Hospital Lattakia Syria.
Skin Health Dis. 2024 Jul 21;4(5):e424. doi: 10.1002/ski2.424. eCollection 2024 Oct.
Linear atrophoderma of Moulin (LAM) is an uncommon dermatological disease characterised by linear, depressed plaques typically following Blaschko's lines. LAM generally occurs in adolescence or early adulthood and is more commonly observed in females. The aetiology of LAM is still unclear. We report a rare case of LAM in an 18-year-old female presenting with an atypical Blaschkoid distribution (multiple band-like pattern) on her right trunk. A clinical examination and histopathological analysis were performed to make the diagnosis. Partial improvement was obtained with calcipotriol and colchicine. LAM is a rare condition; we were only able to identify 23 case reports in the published literature. The findings of this report contribute to the limited literature on LAM, highlighting the clinical variability of LAM and suggesting potential novel variants beyond the classic presentation, emphasising the importance of recognising diverse manifestations for accurate diagnosis and management. Early recognition of LAM is crucial for appropriate treatment and improved patient outcomes. Further research is needed to elucidate LAM's aetiology and underlying mechanisms to facilitate the development of more targeted therapeutic strategies.
穆林线性皮肤萎缩症(LAM)是一种罕见的皮肤病,其特征为通常沿布拉斯科线分布的线性凹陷斑块。LAM一般发生于青春期或成年早期,女性更为常见。LAM的病因仍不清楚。我们报告了一例罕见的LAM病例,患者为一名18岁女性,其右侧躯干出现非典型布拉斯科样分布(多条带状图案)。进行了临床检查和组织病理学分析以明确诊断。使用卡泊三醇和秋水仙碱后病情有部分改善。LAM是一种罕见病症;我们在已发表的文献中仅能找到23例病例报告。本报告的结果丰富了关于LAM的有限文献,突出了LAM的临床变异性,并提示了经典表现之外可能存在的新变体,强调了认识多种表现形式对于准确诊断和管理的重要性。早期识别LAM对于恰当治疗和改善患者预后至关重要。需要进一步研究以阐明LAM的病因和潜在机制,从而推动更具针对性治疗策略的发展。