Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Key Laboratory of New Animal Drug Project, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, Gansu Province, PR China.
China-Kazakh Joint Research Center for Natural Veterinary Drug, Lanzhou 730050, P. R. China.
Nat Prod Rep. 2024 Nov 13;41(11):1652-1722. doi: 10.1039/d4np00023d.
Covering: 2019 to 2023Isoquinoline alkaloids, an important class of -based heterocyclic compounds, have attracted considerable attention from researchers worldwide. To follow up on our prior review (covering 2014-2018) and present the progress of this class of compounds, this review summarizes and provides updated literature on novel isoquinoline alkaloids isolated during the period of 2019-2023, together with their biological activity and underlying mechanisms of action. Moreover, with the rapid development of synthetic modification strategies, the synthesis strategies of isoquinoline alkaloids have been continuously optimized, and the total synthesis of these classes of natural products is reviewed critically herein. Over 250 molecules with a broad range of bioactivities, including antitumor, antibacterial, cardioprotective, anti-inflammatory, neuroprotective and other activities, are isolated and discussed. The total synthesis of more than nine classes of isoquinoline alkaloids is presented, and thirteen compounds constitute the first total synthesis. This survey provides new indications or possibilities for the discovery of new drugs from the original naturally occurring isoquinoline alkaloids.
2019 年至 2023 年异喹啉生物碱是一类重要的基于苯并的杂环化合物，引起了全球研究人员的极大关注。为了跟进我们之前的综述（涵盖 2014 年至 2018 年）并介绍该类化合物的最新进展，本综述总结并提供了 2019 年至 2023 年期间分离得到的新型异喹啉生物碱的文献更新，以及它们的生物活性和作用机制。此外，随着合成修饰策略的快速发展，异喹啉生物碱的合成策略不断得到优化，本文批判性地综述了这些天然产物的全合成。本文共分离并讨论了超过 250 种具有广泛生物活性的分子，包括抗肿瘤、抗菌、心脏保护、抗炎、神经保护等活性。展示了九类以上异喹啉生物碱的全合成，其中 13 个化合物构成了首次全合成。这项研究为从原始天然存在的异喹啉生物碱中发现新药提供了新的指示或可能性。
