Liu Juan, Zhang Qi, Guo Da-Le, Li Mei-Mei, Deng Yun
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Eur J Med Chem. 2025 Oct 15;296:117864. doi: 10.1016/j.ejmech.2025.117864. Epub 2025 Jun 18.
Homoisoflavones, a rare subclass of flavonoids distinguished from isoflavones by an additional carbon atom in their parent structure, have garnered attention for their significant pharmacological properties. Firstly, this review methodically analyzes the structural diversity of all documented homoisoflavone variants and their pharmacological activities, including antibacterial, antitumor, anti-inflammatory, and other biological effects, based on studies spanning from 1973 to the latest accessible data (March 2025). Secondly, the photo-induced synthesis methodologies for homoisoflavones are meticulously scrutinized and elaborated upon, compared with traditional synthetic approaches, as photo-mediated organic synthesis strategy continue to gain prominence as a valuable tool in medicinal chemistry. Finally, based on the structural features, pharmacological activities, and photo-induced synthesis strategies of homoisoflavones, potential future development prospects are proposed. For the first time, this article analyzes the medicinal chemistry potential of homoisoflavones from the perspective of photocatalysis, highlighting their structural features, pharmacological activities, and innovative synthesis strategies. It is hoped that this review will provide valuable guidance for the development of homoisoflavones in medicinal chemistry.
高异黄酮是黄酮类化合物中一个罕见的亚类，其母体结构中比异黄酮多一个碳原子，因其显著的药理特性而受到关注。首先，本综述基于1973年至最新可获取数据（2025年3月）的研究，系统地分析了所有已记录的高异黄酮变体的结构多样性及其药理活性，包括抗菌、抗肿瘤、抗炎和其他生物学效应。其次，与传统合成方法相比，对高异黄酮的光诱导合成方法进行了细致审查和阐述，因为光介导的有机合成策略作为药物化学中的一种有价值工具正日益受到重视。最后，基于高异黄酮的结构特征、药理活性和光诱导合成策略，提出了潜在的未来发展前景。本文首次从光催化的角度分析了高异黄酮的药物化学潜力，突出了它们的结构特征、药理活性和创新合成策略。希望本综述能为高异黄酮在药物化学中的发展提供有价值的指导。
