Marfavi Zeinab, Cai Yuhao, Lv Quanjie, Han Yijun, Yang Ruihao, Sun Kang, Yuan Congli, Tao Ke
State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.
Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.
Nano Lett. 2024 Oct 2. doi: 10.1021/acs.nanolett.4c03668.
Antimicrobial resistance (AMR) is a growing global health concern, necessitating innovative strategies beyond the development of new antibiotics. Here, we employed NdYVO:Eu nanoparticles, which can persistently produce reactive oxygen species (ROS) after stopping the light, as a model of photodynamic nanoparticles and demonstrated that the photodynamic effect can serve as an adjuvant with antibiotics to effectively reduce their minimum inhibitory concentration. These preirradiated nanoparticles could penetrate the bacterial cell membrane, significantly enhancing the potency of antibiotics. We showed that the synergy effect could be attributed to disrupting crucial cellular processes by ROS, including damaging cell membrane proteins, interfering with energy supply, and inhibiting antibiotic metabolism. Our findings suggested that complementing the photodynamic effect might be a robust strategy to enhance antibiotic potency, providing an alternative antibacterial treatment paradigm.
抗菌耐药性（AMR）是一个日益严重的全球健康问题，需要开发新抗生素之外的创新策略。在此，我们使用了钕钇钒酸铕（NdYVO:Eu）纳米颗粒，其在停止光照后能持续产生活性氧（ROS），作为光动力纳米颗粒的模型，并证明光动力效应可作为抗生素的佐剂，有效降低其最低抑菌浓度。这些预辐照的纳米颗粒可穿透细菌细胞膜，显著增强抗生素的效力。我们表明，协同效应可归因于ROS破坏关键细胞过程，包括损伤细胞膜蛋白、干扰能量供应和抑制抗生素代谢。我们的研究结果表明，补充光动力效应可能是增强抗生素效力的有力策略，提供了一种替代的抗菌治疗模式。
