College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China.
Crit Rev Microbiol. 2024 May;50(3):267-284. doi: 10.1080/1040841X.2023.2186215. Epub 2023 Mar 8.
The widespread antimicrobial resistance (AMR) calls for the development of new antimicrobial strategies. Antibiotic adjuvant rescues antibiotic activity and increases the life span of the antibiotics, representing a more productive, timely, and cost-effective strategy in fighting drug-resistant pathogens. Antimicrobial peptides (AMPs) from synthetic and natural sources are considered new-generation antibacterial agents. Besides their direct antimicrobial activity, growing evidence shows that some AMPs effectively enhance the activity of conventional antibiotics. The combinations of AMPs and antibiotics display an improved therapeutic effect on antibiotic-resistant bacterial infections and minimize the emergence of resistance. In this review, we discuss the value of AMPs in the age of resistance, including modes of action, limiting evolutionary resistance, and their designing strategies. We summarise the recent advances in combining AMPs and antibiotics against antibiotic-resistant pathogens, as well as their synergistic mechanisms. Lastly, we highlight the challenges and opportunities associated with the use of AMPs as potential antibiotic adjuvants. This will shed new light on the deployment of synergistic combinations to address the AMR crisis.
广泛存在的抗菌药物耐药性（AMR）要求开发新的抗菌策略。抗生素佐剂可恢复抗生素的活性并延长抗生素的寿命，这是一种更具成效、及时和具有成本效益的对抗耐药病原体的策略。合成和天然来源的抗菌肽（AMPs）被认为是新一代抗菌剂。除了直接的抗菌活性外，越来越多的证据表明，一些 AMPs 可以有效增强常规抗生素的活性。AMP 与抗生素的联合使用对治疗抗生素耐药性细菌感染具有更好的疗效，并最大限度地减少耐药性的产生。在这篇综述中，我们讨论了 AMP 在耐药时代的价值，包括作用模式、限制进化耐药性以及它们的设计策略。我们总结了最近在联合 AMP 和抗生素对抗抗生素耐药病原体方面的进展，以及它们的协同机制。最后，我们强调了将 AMP 用作潜在抗生素佐剂的相关挑战和机遇。这将为解决 AMR 危机提供协同组合的部署提供新的思路。
