在小鼠肿瘤系统中，角鲨烯对3-[(4-氨基-2-甲基-5-嘧啶基)甲基]-1-(2-氯乙基)-亚硝基脲抗肿瘤作用的增强作用。
Potentiation by squalene of antitumor effect of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-nitros ourea in a murine tumor system.
作者信息
Yamaguchi T, Nakagawa M, Hidaka K, Yoshida T, Sasaki T, Akiyama S, Kuwano M
出版信息
Jpn J Cancer Res. 1985 Oct;76(10):1021-6.
PMID:3935620
Abstract
The effect of squalene (SQ) on the antitumor activity of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitros our ea (ACNU) was studied in a murine tumor system. SQ at 4.2 g/kg exhibited a significant potentiating effect on the activity of 10 mg/kg of ACNU against lymphocytic leukemia P388 and resulted in some long-term survivors without toxicity to the host. Simultaneous administration of SQ and ACNU was most effective.
摘要
在小鼠肿瘤系统中研究了角鲨烯（SQ）对3-[(4-氨基-2-甲基-5-嘧啶基)甲基]-1-(2-氯乙基)-1-亚硝基脲（ACNU）抗肿瘤活性的影响。4.2 g/kg的SQ对10 mg/kg的ACNU抗淋巴细胞白血病P388的活性表现出显著的增强作用，并产生了一些对宿主无毒的长期存活者。同时给予SQ和ACNU最为有效。
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