• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

从天然来源获取和测定角鲨烯的方法。

Methods for obtaining and determination of squalene from natural sources.

作者信息

Popa Ovidiu, Băbeanu Narcisa Elena, Popa Ioana, Niță Sultana, Dinu-Pârvu Cristina Elena

机构信息

Department of Industrial Biotechnologies, Faculty of Biotechnologies, University of Agricultural Sciences and Veterinary Medicine Bucharest, 59 Marasti, District 1, 011464 Bucharest, Romania.

Department of Physical-Chemical Analysis and Quality Control, National Institute for Chemical Pharmaceutical Research and Development, 112 Vitan, District 3, 031299 Bucharest, Romania.

出版信息

Biomed Res Int. 2015;2015:367202. doi: 10.1155/2015/367202. Epub 2015 Jan 28.

DOI:10.1155/2015/367202
PMID:25695064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4324104/
Abstract

Squalene is a natural dehydrotriterpenic hydrocarbon (C30H50) with six double bonds, known as an intermediate in the biosynthesis of phytosterol or cholesterol in plants or animals. We have briefly reviewed the natural sources for squalene and focused on the main methods and techniques to obtain and to determine it. Some of its applications in different fields of human activity are also mentioned.

摘要

角鲨烯是一种天然的脱氢三萜碳氢化合物（C30H50），含有六个双键，是植物或动物体内植物甾醇或胆固醇生物合成过程中的一种中间体。我们简要回顾了角鲨烯的天然来源，并重点介绍了获取和测定角鲨烯的主要方法和技术。还提到了它在人类不同活动领域中的一些应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd95/4324104/d79f9d3de725/BMRI2015-367202.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd95/4324104/022cb037bed4/BMRI2015-367202.sch.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd95/4324104/d79f9d3de725/BMRI2015-367202.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd95/4324104/022cb037bed4/BMRI2015-367202.sch.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd95/4324104/d79f9d3de725/BMRI2015-367202.001.jpg

相似文献

1
Methods for obtaining and determination of squalene from natural sources.从天然来源获取和测定角鲨烯的方法。
Biomed Res Int. 2015;2015:367202. doi: 10.1155/2015/367202. Epub 2015 Jan 28.
2
Biosynthetic Approaches to Squalene Production: The Case of Yeast.角鲨烯生产的生物合成方法：以酵母为例。
Methods Mol Biol. 2017;1494:95-106. doi: 10.1007/978-1-4939-6445-1_7.
3
Phytosterols: applications and recovery methods.植物甾醇：应用与回收方法。
Bioresour Technol. 2007 Sep;98(12):2335-50. doi: 10.1016/j.biortech.2006.10.006. Epub 2006 Nov 22.
4
Structural insights on cholesterol endosynthesis: Binding of squalene and 2,3-oxidosqualene to supernatant protein factor.胆固醇内源性合成的结构见解：角鲨烯和2,3-氧化角鲨烯与上清蛋白因子的结合
J Struct Biol. 2015 Jun;190(3):261-70. doi: 10.1016/j.jsb.2015.05.001. Epub 2015 May 16.
5
Noncholesterol sterols.非胆固醇类固醇
Acta Univ Carol Med Monogr. 2008;154:5-101.
6
From squalene to brassinolide: the steroid metabolic and signaling pathways across the plant kingdom.从角鲨烯到油菜素内酯：植物王国中的甾体代谢和信号通路。
Mol Plant. 2013 Nov;6(6):1738-57. doi: 10.1093/mp/sst096. Epub 2013 Jun 12.
7
Cholesterol biosynthesis: studies related to the metabolic role of squalene.胆固醇生物合成：与角鲨烯代谢作用相关的研究
J Clin Invest. 1958 May;37(5):655-9. doi: 10.1172/JCI103650.
8
Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells.培养细胞中胆固醇前体和植物甾醇的气相色谱/质谱联用分析
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jul 15;877(22):2081-6. doi: 10.1016/j.jchromb.2009.05.050. Epub 2009 Jun 12.
9
The importance and perspective of plant-based squalene in cosmetology.植物源角鲨烯在美容学中的重要性及前景
J Cosmet Sci. 2013 Jan-Feb;64(1):59-66.
10
Studies on the biosynthesis of cholesterol. 5. Biosynthesis of squalene from DL-3-hydroxy-3-methyl [2-14C] pentano-5-lactone.胆固醇生物合成的研究。5. 由DL-3-羟基-3-甲基[2-¹⁴C]戊酸-5-内酯生物合成角鲨烯。
Biochem J. 1958 May;69(1):146-55. doi: 10.1042/bj0690146.

引用本文的文献

1
Combining biotechnology with sustainability: feasibility of bioenergy sorghum in generating high-value bioproducts.将生物技术与可持续性相结合：生物能源高粱生产高价值生物产品的可行性。
Biotechnol Lett. 2025 Aug 1;47(4):85. doi: 10.1007/s10529-025-03623-2.
2
MF59-like adjuvant containing yeast-derived squalene enhances the humoral immune response to cell-derived influenza vaccine.含酵母源性角鲨烯的MF59样佐剂可增强对细胞源性流感疫苗的体液免疫反应。
Arch Virol. 2025 May 21;170(6):134. doi: 10.1007/s00705-025-06306-5.
3
Therapeutic potential of thymoquinone in regulating p63, claudin, and periostin in chronic rhinosinusitis with nasal polyps: An animal model study.

本文引用的文献

1
The effect of consecutive steps of refining on squalene content of vegetable oils.连续精炼步骤对植物油中角鲨烯含量的影响。
J Food Sci Technol. 2011 Jun;48(3):382-5. doi: 10.1007/s13197-010-0190-2. Epub 2010 Dec 21.
2
Sebaceous gland lipids.皮脂腺脂质
Dermatoendocrinol. 2009 Mar;1(2):68-71. doi: 10.4161/derm.1.2.8472.
3
Squalene: A natural triterpene for use in disease management and therapy.角鲨烯：一种用于疾病管理和治疗的天然三萜烯。
百里醌对鼻息肉慢性鼻窦炎中p63、紧密连接蛋白和骨膜蛋白的调节作用及其治疗潜力：一项动物模型研究
Narra J. 2025 Apr;5(1):e1728. doi: 10.52225/narra.v5i1.1728. Epub 2025 Mar 16.
4
Molecular Profiling and FTIR Characterization of Wheat Germ Oil, Supported by the Screening of Its Anti-Inflammatory and Cytotoxic Properties.小麦胚芽油的分子谱分析与傅里叶变换红外光谱表征及其抗炎和细胞毒性特性筛选的支持
Biomolecules. 2025 Mar 21;15(4):464. doi: 10.3390/biom15040464.
5
Detection of Mycobacteria in Arabian camels and antimycobacterial potential of Moringa oleifera.阿拉伯骆驼体内分枝杆菌的检测及辣木的抗分枝杆菌潜力
Sci Rep. 2025 Apr 4;15(1):11590. doi: 10.1038/s41598-025-92402-0.
6
Changes in key volatile components associated with leaf quality of Roxb. alongside growth duration.与罗克斯伯（Roxb.）叶片质量相关的关键挥发性成分随生长时间的变化。
Food Chem X. 2024 Dec 24;25:102126. doi: 10.1016/j.fochx.2024.102126. eCollection 2025 Jan.
7
Analytical Determination of Squalene in Extra Virgin Olive Oil and Olive Processing By-Products, and Its Valorization as an Ingredient in Functional Food-A Critical Review.分析测定特级初榨橄榄油和橄榄油加工副产物中的角鲨烯及其作为功能性食品成分的增值——综述评论。
Molecules. 2024 Nov 3;29(21):5201. doi: 10.3390/molecules29215201.
8
Microbial Squalene: A Sustainable Alternative for the Cosmetics and Pharmaceutical Industry - A Review.微生物角鲨烯：化妆品和制药行业的可持续替代方案——综述
Eng Life Sci. 2024 Aug 27;24(10):e202400003. doi: 10.1002/elsc.202400003. eCollection 2024 Oct.
9
Tailored UPRE2 variants for dynamic gene regulation in yeast.定制化的 UPRE2 变体用于酵母中的动态基因调控。
Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2315729121. doi: 10.1073/pnas.2315729121. Epub 2024 Apr 30.
10
Non-targeted discovery of high-value bio-products in Nicotiana glauca L: a potential renewable plant feedstock.在黄花烟草中无靶向发现高价值生物产品：一种潜在的可再生植物原料。
Bioresour Bioprocess. 2024 Jan 18;11(1):12. doi: 10.1186/s40643-023-00726-4.
Adv Drug Deliv Rev. 2009 Dec 17;61(15):1412-26. doi: 10.1016/j.addr.2009.09.005. Epub 2009 Oct 2.
4
Squalene emulsions for parenteral vaccine and drug delivery.用于肠胃外疫苗和药物递送的角鲨烯乳剂。
Molecules. 2009 Sep 1;14(9):3286-312. doi: 10.3390/molecules14093286.
5
Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology.角鲨烯及相关化合物的生物学和药理学活性：在美容皮肤科的潜在用途。
Molecules. 2009 Jan 23;14(1):540-54. doi: 10.3390/molecules14010540.
6
Thematic review series: skin lipids. Sebaceous gland lipids: friend or foe?专题综述系列：皮肤脂质。皮脂腺脂质：是友还是敌？
J Lipid Res. 2008 Feb;49(2):271-81. doi: 10.1194/jlr.R700015-JLR200. Epub 2007 Nov 1.
7
Identification of oxidation products of squalene in solution and in latent fingerprints by ESI-MS and LC/APCI-MS.通过电喷雾电离质谱（ESI-MS）和液相色谱/大气压化学电离质谱（LC/APCI-MS）鉴定溶液中和潜在指纹中的角鲨烯氧化产物。
Anal Chem. 2007 Apr 1;79(7):2650-7. doi: 10.1021/ac0623944. Epub 2007 Mar 8.
8
Amaranth oil application for coronary heart disease and hypertension.苋菜油在冠心病和高血压治疗中的应用。
Lipids Health Dis. 2007 Jan 5;6:1. doi: 10.1186/1476-511X-6-1.
9
Cardioprotective effect of squalene on lipid profile in isoprenaline-induced myocardial infarction in rats.角鲨烯对异丙肾上腺素诱导的大鼠心肌梗死血脂水平的心脏保护作用。
J Med Food. 2006 Winter;9(4):531-6. doi: 10.1089/jmf.2006.9.531.
10
Fatty acid profile, tocopherol, squalene and phytosterol content of brazil, pecan, pine, pistachio and cashew nuts.巴西坚果、山核桃、松子、开心果和腰果的脂肪酸谱、生育酚、角鲨烯和植物甾醇含量。
Int J Food Sci Nutr. 2006 May-Jun;57(3-4):219-28. doi: 10.1080/09637480600768077.