Ochiai A, Yokozaki H, Kyo E, Hozumi T, Tahara E
Jpn J Cancer Res. 1985 Oct;76(10):915-8.
A monoclonal antibody 9A3 was raised to human gastric carcinoma cell line TMK-1, a poorly differentiated adenocarcinoma of the stomach. 9A3 antibody (IgG1, kappa) strongly reacted with various carcinomas immunohistochemically, but did not react with any normal tissues of the whole body tested except for neutrophiles and macrophages. 9A3 antibody also reacted with the luminal surface of the fetal colon and esophagus at six months of gestation. The antigen recognized by 9A3 antibody might be an oncodevelopmental antigen.
一种单克隆抗体9A3是针对人胃癌细胞系TMK - 1产生的，TMK - 1是一种低分化胃腺癌。9A3抗体（IgG1，κ）在免疫组织化学上与各种癌强烈反应，但除了中性粒细胞和巨噬细胞外，与所检测的全身任何正常组织均无反应。9A3抗体在妊娠6个月时也与胎儿结肠和食管的管腔表面发生反应。9A3抗体识别的抗原可能是一种肿瘤发育抗原。
