Nanosensor Bioplatforms Laboratory, Chemistry and Chemical Engineering Research Center of Iran, Tehran 14335-186, Iran.
IMTEK - Department of Microsystems Engineering, University of Freiburg, Freiburg 79110, Germany.
ACS Nano. 2024 Oct 15;18(41):28012-28025. doi: 10.1021/acsnano.4c06191. Epub 2024 Oct 2.
Despite substantial progress in the diagnosis of jaundice/hyperbilirubinemia as the most common disease and cause of hospitalization of newborns, on the eve of Industry/Healthcare 5.0, the development of accurate and reliable wearable diagnostic sensors for noninvasive smart monitoring of bilirubin (BIL) is still in high demand. Aiming to fabricate a smart wearable sensor for early diagnosis of neonatal jaundice and its therapeutic monitoring, we here report a fluorescent dermal nanotattoo that further coupled with an IoT-integrated wearable optoelectronic reader for minimally invasive, continuous, and real-time monitoring of BIL in interstitial fluid. Selective recovery of quenched fluorescence of the dermal tattoo sensor, composed of biocompatible dissolving/hydrogel microneedles loaded with fluorescent carbon quantum dots, upon blue light exposure used for jaundice phototherapy was utilized for highly selective BIL sensing. The fascinating features of our developed smart wearable tattoo sensor and its successful results with high correlation with blood BIL results make it a highly promising sensor for easy, minimally invasive, reliable, and smart eDiagnostics and continuous therapeutic eMonitoring of jaundice and other BIL-induced diseases at the point of care. We envision that the developed nanotattoo sensing bioplatform will inspire the development of future smart tattoo sensors in various diagnostic and monitoring scenarios.
尽管在诊断黄疸/高胆红素血症方面取得了重大进展，这是新生儿最常见的疾病和住院原因，但在工业/医疗保健 5.0 时代到来之际，仍迫切需要开发准确可靠的可穿戴诊断传感器，用于对胆红素 (BIL) 进行非侵入性的智能监测。为了制造一种用于早期诊断新生儿黄疸和治疗监测的智能可穿戴传感器，我们在此报告了一种荧光皮肤纳米纹身，它进一步与物联网集成的可穿戴光电读取器结合，用于对间质液中的 BIL 进行微创、连续和实时监测。利用蓝色光暴露对包含生物相容性溶解/水凝胶微针的皮肤纹身传感器进行荧光猝灭的选择性恢复，这些微针负载有荧光碳量子点，用于黄疸光疗，从而实现对 BIL 的高选择性检测。我们开发的智能可穿戴纹身传感器的迷人特点及其与血液 BIL 结果高度相关的结果，使其成为一种极具前途的传感器，可用于在护理点轻松、微创、可靠和智能地进行 e 诊断，并对黄疸和其他由 BIL 引起的疾病进行连续治疗 e 监测。我们设想，所开发的纳纹传感生物平台将激发未来在各种诊断和监测场景中智能纹身传感器的发展。
