Watanabe N, Niitsu Y, Sone H, Neda H, Yamauchi N, Urushizaki I
Jpn J Cancer Res. 1985 Oct;76(10):989-94.
The inhibitory effect of tumor necrosis serum (TNS) on the artificial metastasis of B-16 melanoma cells and the spontaneous metastasis of Lewis lung carcinoma cells was investigated. The results obtained were as follows: 1) When tumor necrosis serum (TNS) was administered either 20 min or 2 days after injection of B-16 melanoma cells, a very strong inhibitory effect (99%) relative to the control was noted. 2) TNS showed a 60% inhibitory effect on spontaneous metastasis, and the weight of the original tumor regressed by 60%. 3) No histological changes in normal tissues were observed microscopically following TNS injection. The above results confirm that TNS is extremely effective in preventing metastasis.
研究了肿瘤坏死血清（TNS）对B-16黑色素瘤细胞人工转移和Lewis肺癌细胞自发转移的抑制作用。得到的结果如下：1）在注射B-16黑色素瘤细胞后20分钟或2天给予肿瘤坏死血清（TNS），相对于对照组观察到非常强的抑制作用（99%）。2）TNS对自发转移显示出60%的抑制作用，原发肿瘤重量减轻60%。3）注射TNS后，显微镜下未观察到正常组织的组织学变化。上述结果证实TNS在预防转移方面极其有效。
