Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, India.
Institute of Pharmaceutical Research, GLA University, Mathura, UP, India.
Pathol Res Pract. 2024 Nov;263:155619. doi: 10.1016/j.prp.2024.155619. Epub 2024 Sep 28.
Lung cancer remains an intractable malignancy worldwide, prompting novel therapeutic modalities. Pyroptosis, a lethal form of programmed cell death featured by inflammation, has been involved in cancer progression and treatment response. Simultaneously, non-coding RNA has been shown to have important roles in coordinating pattern formation and oncogenic pathways, including long non-coding RNA (lncRNAs), microRNA (miRNAs), circular RNA (circRNAs), and small interfering RNA (siRNAs). Recent studies have revealed that ncRNAs can promote or inhibit pyroptosis by interacting with key molecular players such as NLRP3, GSDMD, and various transcription factors. This dual role of ncRNAs offers a unique therapeutic potential to manipulate pyroptosis pathways, providing opportunities for innovative cancer treatments. In this review, we integrate current research findings to propose novel strategies for leveraging ncRNA-mediated pyroptosis as a therapeutic intervention in lung cancer. We explore the potential of ncRNAs as biomarkers for predicting patient response to treatment and as targets for overcoming resistance to conventional therapies.
肺癌仍然是全球范围内一种难以治愈的恶性肿瘤，促使人们寻求新的治疗方法。细胞焦亡是一种程序性细胞死亡的致命形式，其特征是炎症，它参与了癌症的进展和治疗反应。同时，非编码 RNA 在协调形态发生和致癌途径方面发挥着重要作用，包括长链非编码 RNA（lncRNA）、微小 RNA（miRNA）、环状 RNA（circRNA）和小干扰 RNA（siRNA）。最近的研究表明，ncRNA 可以通过与 NLRP3、GSDMD 和各种转录因子等关键分子靶点相互作用，促进或抑制细胞焦亡。ncRNA 的这种双重作用为操纵细胞焦亡途径提供了独特的治疗潜力，为创新的癌症治疗提供了机会。在这篇综述中，我们整合了当前的研究结果，提出了利用 ncRNA 介导的细胞焦亡作为肺癌治疗干预的新策略。我们探讨了 ncRNA 作为预测患者对治疗反应的生物标志物和克服对传统治疗耐药性的靶标的潜力。
