Sino-French Hoffmann Institute, School of Basic Medical Sciences, The Second Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, China.
Sino-French Hoffmann Institute, School of Basic Medical Sciences, The Second Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, China; Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, China.
Int Immunopharmacol. 2024 Dec 25;143(Pt 1):113229. doi: 10.1016/j.intimp.2024.113229. Epub 2024 Oct 1.
T-bet and Eomes, both T-box transcription factors, have been extensively studied for their critical roles in the differentiation and functional maintenance of various immune cells. In this review, we provide a focused overview of their contributions to the transcriptional activation and differentiation, development, and terminal maturation of natural killer cells and innate lymphoid cell 1 cells. Furthermore, the interplay between T-bet and Eomes in regulating NK cell function, and its subsequent implications for immune responses against infections and tumors, is thoroughly examined. The review explores the ramifications of dysregulated transcription factor expression, examining its impact on homeostatic balance and its role in a spectrum of disease models. Expression variances among distinct NK cell subsets resident in different tissues are highlighted to underscore the complexity of their biological roles. Collectively, this work aims to expand the current understanding of NK cell biology, thereby paving the way for innovative approaches in the realm of NK cell-based immunotherapies.
T-bet 和 Eomes 都是 T 盒转录因子，它们在各种免疫细胞的分化和功能维持中起着关键作用，因此受到了广泛的研究。在这篇综述中，我们重点介绍了它们在自然杀伤细胞和先天淋巴样细胞 1 细胞的转录激活和分化、发育和终末成熟中的作用。此外，我们还深入研究了 T-bet 和 Eomes 之间的相互作用如何调节 NK 细胞的功能，以及它们对感染和肿瘤免疫反应的后续影响。该综述探讨了转录因子表达失调的影响，研究了其对体内平衡的影响以及在一系列疾病模型中的作用。还强调了不同 NK 细胞亚群在不同组织中的表达差异，以突出其生物学作用的复杂性。总的来说，这项工作旨在扩展对 NK 细胞生物学的现有理解，为基于 NK 细胞的免疫疗法领域的创新方法铺平道路。
