Institute of Respiratory Diseases, Xiamen Medical College, Xiamen, Fujian Province 361023, PR China; Fujian Provincial Key Laboratory of Functional and Clinical Translational Medicine, Xiamen Medical College, Xiamen, Fujian Province 361023, PR China; Department of Clinical Medicine, Xiamen Medical College, Xiamen, Fujian Province 361023, PR China.
Institute of Respiratory Diseases, Xiamen Medical College, Xiamen, Fujian Province 361023, PR China; Fujian Provincial Key Laboratory of Functional and Clinical Translational Medicine, Xiamen Medical College, Xiamen, Fujian Province 361023, PR China.
Heart Lung. 2025 Jan-Feb;69:71-77. doi: 10.1016/j.hrtlng.2024.09.014. Epub 2024 Oct 1.
Many studies have reported correlations between diet-derived antioxidants and asthma. Nevertheless, the probable association between diet-derived antioxidants and asthma remains a matter of discussion.
We explored the association between Diet-Derived Antioxidants and Asthma.
We used data from the 2003-2018 National Health and Nutrition Examination Survey (NHANES) to assess the relationship between diet-derived antioxidants and asthma and a two-sample Mendelian randomization (MR) study was employed to assess the causal associations between lifelong diet-derived circulating antioxidant levels and the risk of asthma.
Participants with asthma were more likely to be young-to-middle-aged females, smokers, have lower income, belong to non-Hispanic Black ethnicity, have a high school education, have a BMI over 30. The dietary intakes of vitamin C, zinc, selenium, and CDAI were negatively associated with asthma risk (Vitamin C: OR = 0.76, 95 % CI: 0.63-0.91, P = 0.032; Zinc: OR = 0.86, 95 % CI: 0.75-1.00, P = 0.046; Selenium: OR = 0.85, 95 % CI: 0.73-0.98, P = 0.004; CDAI: OR = 0.80, 95 % CI: 0.65-0.97, P = 0.027). There was a significant nonlinear relationship between the dietary intake of vitamin C, zinc, and selenium and the risk of asthma (P < 0.05). However, no causal link between circulating antioxidants and asthma risk was found in the MR analysis. Sensitivity analyses supported the robustness of the results.
In the observational study, we identified a negative correlation between the dietary intake of vitamin C, zinc, selenium, and CDAI and asthma risk, while our MR analyses did not find evidence to support a causal relationship between diet-derived antioxidants and the risk of asthma.
许多研究报告了饮食源性抗氧化剂与哮喘之间的相关性。然而，饮食源性抗氧化剂与哮喘之间的可能关联仍然存在争议。
我们探讨了饮食源性抗氧化剂与哮喘之间的关系。
我们使用了 2003-2018 年全国健康和营养调查（NHANES）的数据来评估饮食源性抗氧化剂与哮喘之间的关系，并进行了两样本孟德尔随机化（MR）研究，以评估终身饮食源性循环抗氧化剂水平与哮喘风险之间的因果关系。
患有哮喘的参与者更有可能是年轻到中年的女性、吸烟者、收入较低、属于非西班牙裔黑人、具有高中学历、BMI 超过 30。维生素 C、锌、硒和 CDAI 的饮食摄入量与哮喘风险呈负相关（维生素 C：OR=0.76，95%CI：0.63-0.91，P=0.032；锌：OR=0.86，95%CI：0.75-1.00，P=0.046；硒：OR=0.85，95%CI：0.73-0.98，P=0.004；CDAI：OR=0.80，95%CI：0.65-0.97，P=0.027）。维生素 C、锌和硒的饮食摄入量与哮喘风险之间存在显著的非线性关系（P<0.05）。然而，MR 分析并未发现循环抗氧化剂与哮喘风险之间存在因果关系。敏感性分析支持了结果的稳健性。
在观察性研究中，我们发现维生素 C、锌、硒和 CDAI 的饮食摄入量与哮喘风险呈负相关，而我们的 MR 分析没有发现证据支持饮食源性抗氧化剂与哮喘风险之间存在因果关系。
