Department of Environmental Health, School of Public Health, Shanxi Medical University, Taiyuan 030001, China; Yellow River Basin Ecological Public Health Security Center, Shanxi Medical University, Taiyuan 030001, China; MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan 030001, China.
Yuncheng Central Hospital, Yuncheng 044000, China.
Ecotoxicol Environ Saf. 2024 Oct 15;285:117088. doi: 10.1016/j.ecoenv.2024.117088. Epub 2024 Oct 1.
Identified as a critical risk factor for childhood asthma, environmental pollution plays a pivotal role. However, research on the effects and mechanisms of phthalates mixture and their interactions in relation to childhood asthma is still lacking. In the National Health and Nutrition Examination Survey (NHANES) conducted from 2009 to 2018, our research explored the link between phthalates in urine and the prevalence of childhood asthma. In this study, which involved 810 participants, we used four different statistical analysis methods to investigate the association between urinary phthalate levels and childhood asthma. Additionally, we conducted a mediation analysis to explore whether the impact mechanism of phthalate exposure on childhood asthma operates through the glycolysis. Among the participants, 525 (64.81 %) individuals were diagnosed with asthma, with 330 (40.74 %) individuals undergoing testing for glycolytic markers. Through Spearman correlation analysis and weighted principal component analysis (W-PCA), it was found that mono-2-ethyl-5-carboxypentyl phthalate (MECPP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl)-hexyl phthalate (MEHP) and mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) are the four most highly correlated phthalates. In addition, comprehensive analysis by the weighted generalized linear models (W-GLM), weighted quantile sum (WQS) and Bayesian kernel machine regression (BKMR) models showed that phthalates mixture were positively associated with the prevalence of childhood asthma, especially MECPP, MEHHP and MEOHP. More importantly, glycolysis participated as a mediator in the relationship between MECPP, MEHHP and MEOHP exposure and the prevalence of childhood asthma, explaining 41.194 %, 38.322 % and 39.871 % of the effects respectively. Therefore, our study revealed that phthalate exposure is a risk factor for asthma in children, and glycolysis may be involved as a potential mediator in this process. This conclusion will be verified through more prospective studies in the future.
作为儿童哮喘的一个关键危险因素，环境污染起着关键作用。然而，有关邻苯二甲酸酯混合物的影响和作用机制及其与儿童哮喘关系的研究仍然缺乏。在 2009 年至 2018 年进行的全国健康和营养检查调查（NHANES）中，我们的研究探讨了尿液中邻苯二甲酸酯与儿童哮喘患病率之间的联系。在这项涉及 810 名参与者的研究中，我们使用了四种不同的统计分析方法来研究尿液中邻苯二甲酸酯水平与儿童哮喘之间的关联。此外，我们进行了中介分析，以探讨邻苯二甲酸酯暴露对儿童哮喘的影响机制是否通过糖酵解起作用。在参与者中，525 人（64.81%）被诊断患有哮喘，其中 330 人（40.74%）进行了糖酵解标志物测试。通过 Spearman 相关分析和加权主成分分析（W-PCA），发现单-2-乙基-5-羧基戊基邻苯二甲酸酯（MECPP）、单-（2-乙基-5-羟基己基）邻苯二甲酸酯（MEHHP）、单-（2-乙基）己基邻苯二甲酸酯（MEHP）和单-（2-乙基-5-氧代己基）邻苯二甲酸酯（MEOHP）是相关性最高的四种邻苯二甲酸酯。此外，加权广义线性模型（W-GLM）、加权分位数总和（WQS）和贝叶斯核机器回归（BKMR）模型的综合分析表明，邻苯二甲酸酯混合物与儿童哮喘的患病率呈正相关，尤其是 MECPP、MEHHP 和 MEOHP。更重要的是，糖酵解作为 MECPP、MEHHP 和 MEOHP 暴露与儿童哮喘患病率之间关系的中介参与其中，分别解释了 41.194%、38.322%和 39.871%的效应。因此，我们的研究表明，邻苯二甲酸酯暴露是儿童哮喘的一个危险因素，糖酵解可能是这一过程中的一个潜在中介。这一结论将通过未来更多的前瞻性研究得到验证。
