Neuroscience of Addiction (NofA) Lab, Department of Psychology, Education & Child Studies, Erasmus University Rotterdam, the Netherlands.
Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands.
J Psychiatr Res. 2024 Nov;179:341-350. doi: 10.1016/j.jpsychires.2024.09.030. Epub 2024 Sep 25.
Cannabis policies and attitudes play a role in the development and presentation of cannabis use disorder (CUD), but it is unclear how these factors are related to biomarkers of addiction. The current study examined cross-cultural differences in cannabis attitudes, cannabis cue-reactivity in the brain and its associations with cannabis use measures and cannabis attitudes.
Cross-sectional fMRI study.
The Netherlands (NL) and Texas (TX), USA.
104 cannabis users with CUD (44% female; NL-CUD = 54, TX-CUD = 50) and 83 non-using controls (52% female; NL-CON = 50, TX-CON = 33).
Self-reported positive (perceived benefits) and negative (perceived harms) cannabis attitudes and tactile cannabis cue-reactivity assessed using a 3T MRI scanner.
While the CUD group overall was more positive and less negative about cannabis and reported higher craving, the TX-CUD group reported significantly more positive and less negative attitudes and less craving than the NL-CUD group. Cannabis cue-reactivity was observed in the CUD group in clusters including the precuneus, lateral occipital cortex, frontal medial cortex, nucleus accumbens, and thalamus. In the TX-CUD group, a positive association was observed between symptom severity and cue-induced craving and cannabis cue-reactivity in precuneus and occipital cortex clusters, while a negative association was observed in the NL-CUD group. In these clusters, individuals with more positive attitudes exhibited a positive association between craving and cue-reactivity and those with less positive attitudes exhibited a negative association. No associations with quantity of use were observed.
Cue-induced craving might be deferentially associated with cannabis cue-reactivity across distinct cannabis use environments.
大麻政策和态度在大麻使用障碍（CUD）的发展和表现中起着作用，但尚不清楚这些因素与成瘾生物标志物有何关联。本研究旨在检验不同文化背景下的大麻态度、大脑对大麻线索的反应差异，及其与大麻使用情况和大麻态度的关系。
横断面 fMRI 研究。
荷兰（NL）和美国德克萨斯州（TX）。
104 名大麻使用障碍患者（44%为女性；NL-CUD=54 名，TX-CUD=50 名）和 83 名非使用者对照（52%为女性；NL-CON=50 名，TX-CON=33 名）。
自我报告的大麻正性（感知益处）和负性（感知危害）态度以及使用 3T MRI 扫描仪评估的触觉大麻线索反应。
尽管 CUD 组整体上对大麻的看法更为积极，对大麻的负面看法较少，且报告的渴求感更高，但与 NL-CUD 组相比，TX-CUD 组对大麻的正性和负性态度以及渴求感均较低。在 CUD 组中，观察到大麻线索反应的集群包括楔前叶、外侧枕叶皮质、额内侧皮质、伏隔核和丘脑。在 TX-CUD 组中，症状严重程度与线索诱发的渴求感以及楔前叶和枕叶皮质集群中的大麻线索反应呈正相关，而在 NL-CUD 组中呈负相关。在这些集群中，具有更积极态度的个体表现出渴求感与线索反应之间的正相关，而具有较不积极态度的个体表现出负相关。未观察到与使用量的相关性。
在不同的大麻使用环境中，线索诱发的渴求感可能与大麻线索反应存在差异相关。
