Seoul National University, Seoul, Republic of Korea.
Institute of Sports Science, Seoul National University, Seoul, Republic of Korea.
Geriatr Gerontol Int. 2024 Nov;24(11):1156-1164. doi: 10.1111/ggi.14987. Epub 2024 Oct 2.
This study investigated the association of physical activity (PA) levels with all-cause and cardiovascular disease (CVD) mortality risks stratified by adiposity and age.
Participants (36 703; mean age: 49.1; 57.1% women) were selected from the Korea National Health and Nutrition Examination Survey 2007-2013. A Cox proportional hazards model was used to examine the association between PA and mortality across different adiposity categories and ages.
Median follow-up was 9.22 years; 2393 individuals died, including 538 with CVD. Compared with normal-weight controls, underweight individuals had increased all-cause mortality risk (hazard ratio [HR]: 1.60, 95% confidence interval [CI]: 1.33-1.79). The overweight and obese groups demonstrated reduced mortality risks (HRs: 0.75 [95% CI: 0.67-0.84] and 0.59 [95% CI: 0.51-0.67], respectively). Mortality risk based on abdominal obesity had an HR of 1.22 (95% CI: 1.08-1.37). PA protected against mortality risk most in the obese group performing more than 1000 MET-min/week and was particularly significant among those who were underweight and obese aged 65 and older.
Overweight and obese Asian individuals (based on body mass index) had a lower mortality risk than those with normal body mass index, whereas obesity based on waist circumference was associated with increased mortality. PA protected against mortality across various weight categories, especially in individuals aged ≥65. Geriatr Gerontol Int 2024; 24: 1156-1164.
本研究旨在调查体力活动（PA）水平与肥胖程度和年龄分层的全因和心血管疾病（CVD）死亡率风险的相关性。
参与者（36703 人；平均年龄：49.1 岁；57.1%为女性）选自 2007-2013 年韩国国家健康与营养检查调查。使用 Cox 比例风险模型来检查 PA 与不同肥胖类别和年龄的死亡率之间的关系。
中位随访时间为 9.22 年；有 2393 人死亡，其中 538 人死于 CVD。与正常体重对照组相比，体重不足者的全因死亡风险增加（风险比 [HR]：1.60，95%置信区间 [CI]：1.33-1.79）。超重和肥胖组的死亡风险降低（HRs：0.75 [95% CI：0.67-0.84] 和 0.59 [95% CI：0.51-0.67]）。基于腹型肥胖的死亡率风险的 HR 为 1.22（95% CI：1.08-1.37）。PA 对肥胖组（每周进行超过 1000 代谢当量分钟的活动）的保护作用最大，对体重不足和 65 岁及以上超重和肥胖者的保护作用尤其显著。
超重和肥胖的亚洲个体（基于体重指数）的死亡率风险低于正常体重指数者，而基于腰围的肥胖与死亡率升高相关。PA 对各种体重类别中的死亡率具有保护作用，特别是在年龄≥65 岁的个体中。
