Frankel A E
J Biol Response Mod. 1985 Oct;4(5):437-46.
Immunotoxins are protein molecules composed of monoclonal antibodies linked covalently to either peptide toxins or polypeptides related to toxins. These molecules can be used in the therapy of a number of malignant diseases including lymphoma, leukemia, and solid tumors. They can be used to prevent graft-versus-host disease or rejection in transplanted organs, such as bone marrow and pancreas. The design and development of these molecules, as well as a clinical development plan, will be discussed.
免疫毒素是由单克隆抗体与肽毒素或与毒素相关的多肽共价连接而成的蛋白质分子。这些分子可用于治疗多种恶性疾病，包括淋巴瘤、白血病和实体瘤。它们可用于预防移植器官（如骨髓和胰腺）中的移植物抗宿主病或排斥反应。将讨论这些分子的设计与开发以及临床开发计划。
