Frankel A E, Houston L L, Issell B F, Fathman G
Annu Rev Med. 1986;37:125-42. doi: 10.1146/annurev.me.37.020186.001013.
Immunotoxins are formed by chemically linking antibodies to "toxic" polypeptides that inactivate protein synthesis. These hybrid protein molecules are guided to tumor cells by the antibody moiety, and once bound to the tumor cells, the toxic polypeptide moiety penetrates the cell membrane and enzymatically inactivates protein synthesis. A stepwise approach to identifying the potential clinical uses of immunotoxins in cancer therapy is examined in this chapter.
免疫毒素是通过将抗体与使蛋白质合成失活的“毒性”多肽化学连接而形成的。这些杂合蛋白质分子由抗体部分引导至肿瘤细胞，一旦与肿瘤细胞结合，毒性多肽部分就会穿透细胞膜并通过酶促作用使蛋白质合成失活。本章探讨了一种逐步确定免疫毒素在癌症治疗中潜在临床用途的方法。
