Department of Neurology, The First Hospital of Jilin University, Changchun, China.
Department of Neurology, The First Hospital of Jilin University, Changchun, China.
Life Sci. 2024 Nov 15;357:123088. doi: 10.1016/j.lfs.2024.123088. Epub 2024 Sep 30.
Parkinson's disease (PD), a neurodegenerative disorder characterized by impaired motor function, is typically treated with medications and surgery. However, recent studies have validated physical exercise as an effective adjunct therapy, significantly improving both motor and non-motor symptoms in PD patients. Irisin, a myokine, has garnered increasing attention for its beneficial effects on the nervous system. Research has shown that irisin plays a crucial role in regulating metabolic balance, optimizing autophagy, maintaining mitochondrial quality, alleviating oxidative stress and neuroinflammation, and regulating cell death-all processes intricately linked to the pathogenesis of PD. This review examines the mechanisms through which irisin may counteract PD, provides insights into its biological effects, and considers its potential as a target for therapeutic strategies.
帕金森病（PD）是一种以运动功能受损为特征的神经退行性疾病，通常采用药物和手术治疗。然而，最近的研究已经证实，体育锻炼是一种有效的辅助治疗方法，可显著改善 PD 患者的运动和非运动症状。鸢尾素作为一种肌肉因子，因其对神经系统的有益作用而受到越来越多的关注。研究表明，鸢尾素在调节代谢平衡、优化自噬、维持线粒体质量、减轻氧化应激和神经炎症以及调节细胞死亡等方面发挥着关键作用，所有这些过程都与 PD 的发病机制密切相关。本综述探讨了鸢尾素对抗 PD 的作用机制，阐述了其生物学效应，并考虑了其作为治疗策略靶点的潜力。
