Du Xiao H, Huang Su Y, Zeng Xiao F, Lu Si J, Gao Zhe
Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou, China.
Department of Pathology, Hangzhou Third People's Hospital, Hangzhou, China.
J Cutan Pathol. 2025 Jan;52(1):16-19. doi: 10.1111/cup.14728. Epub 2024 Oct 2.
Wolf isotopic response (WIR) is a phenomenon in which a second, unrelated skin disease arises at the same site as a previously healed dermatosis. WIR most commonly occurs in healed herpes zoster but has also been described in other conditions, such as herpes simplex virus, varicella-zoster virus, and skin tumors. Acquired perforating dermatosis (APD) is characterized by transepidermal elimination of collagen bundles that lead to the development of ulcerative papules, which are often associated with systemic conditions such as diabetes or renal failure. This report documents a rare occurrence of APD after WIR and reviews related published works.
沃尔夫同位素反应（WIR）是一种现象，即第二种不相关的皮肤病出现在先前已愈合的皮肤病灶的同一部位。WIR最常见于愈合的带状疱疹，但也在其他病症中有所描述，如单纯疱疹病毒、水痘-带状疱疹病毒和皮肤肿瘤。获得性穿通性皮肤病（APD）的特征是胶原束经表皮排出，导致溃疡性丘疹的形成，这些丘疹通常与糖尿病或肾衰竭等全身性疾病有关。本报告记录了WIR后罕见发生的APD病例，并回顾了相关的已发表文献。
