Wolf R, Brenner S, Ruocco V, Filioli F G
Department of Dermatology, Tel-Aviv Sourasky Medical Center, Ichilov Hospital, Israel.
Int J Dermatol. 1995 May;34(5):341-8. doi: 10.1111/j.1365-4362.1995.tb03616.x.
The occurrence of a new skin disorder exactly at the site of another one, already healed and unrelated, was first described in 1955. In 1985, Wolf et al. recognized that we are dealing with a dermatologic phenomenon and established a precise definition for this phenomenon. Fifty-eight cases corresponding to the definition of this phenomenon have been reported until now.
The new phenomenon, for which the term "isotopic response" has been suggested, has been defined. Cases corresponding to the definition have been analyzed with special emphasis on the diseases involved, the time intervals, and the locations of the diseases. Eight new cases are described.
A total of 58 cases of isotopic response have been described. The first disease in most of the patients was herpes zoster; in three cases it was herpes simplex, in two varicella, and in one, thrombophlebitis. The second disease, which appeared exactly at the site of the first, already healed disease, was in most reported cases a carcinoma (26 cases, in particular 15 cases of breast carcinoma, 5 basal cell carcinomas (BCC), 4 squamous cell carcinomas (SCC), 2 basosquamous carcinomas), or granuloma annulare (16 cases). Additional diseases were Kaposi's sarcoma (2 cases), pseudolymphoma (2 cases), sarcoid (2 cases), tinea (2 cases), tuberculoid and vasculitis granuloma (1 case), angiosarcoma, metastasis, Bowen's disease, lymphoma, leukemia cutis, and acne (1 case each). The diseases did not show any predilection for a particular location. The interval between the first and second disease was extremely variable (ranging from days to years) and showed no particular features. In the eight additional cases described in the present report, the first disease was herpes simplex (6 cases) or herpes zoster (2 cases). The second disease was viral warts (3 cases) or squamous cell carcinoma (2 cases). Additional diseases were furunculosis, contact dermatitis, and molluscum contagiosum (1 case each).
The new term, "isotopic response," describes the occurrence of a new skin disorder at the site of another, unrelated, and already healed skin disease. It is suggested that the term "isotopic response" be included in the lexicon (glossary) of dermatology. Introducing the new term and classifying all the cases under a single key word, will make it possible to locate and collect them easily and to search for the mechanism underlying this phenomenon.
1955年首次描述了一种新的皮肤疾病恰好出现在另一种已愈合且不相关的皮肤疾病部位的情况。1985年，沃尔夫等人认识到我们正在处理一种皮肤病学现象，并为这一现象确立了精确的定义。截至目前，已有58例符合该现象定义的病例被报道。
已对这种被建议称为“同位素反应”的新现象进行了定义。对符合该定义的病例进行了分析，特别关注所涉及的疾病、时间间隔和疾病发生部位。描述了8例新病例。
共描述了58例同位素反应病例。大多数患者的首发疾病为带状疱疹；3例为单纯疱疹，2例为水痘，1例为血栓性静脉炎。在大多数报道的病例中，恰好出现在首发已愈合疾病部位的第二种疾病为癌（26例，特别是15例乳腺癌、5例基底细胞癌、4例鳞状细胞癌、2例基底鳞状细胞癌）或环状肉芽肿（16例）。其他疾病包括卡波西肉瘤（2例）、假性淋巴瘤（2例）、结节病（2例）、癣（2例）、结核样和血管炎肉芽肿（1例）、血管肉瘤、转移瘤、鲍温病、淋巴瘤、皮肤白血病和痤疮（各1例）。这些疾病在特定部位无任何偏好。首发疾病与第二种疾病之间的间隔差异极大（从数天到数年），且无特殊特征。在本报告描述的另外8例病例中，首发疾病为单纯疱疹（6例）或带状疱疹（2例）。第二种疾病为病毒疣（3例）或鳞状细胞癌（2例）。其他疾病包括疖病、接触性皮炎和传染性软疣（各1例）。
新术语“同位素反应”描述了一种新的皮肤疾病出现在另一种不相关且已愈合的皮肤疾病部位的情况。建议将“同位素反应”这一术语纳入皮肤病学词汇表（术语汇编）。引入这个新术语并将所有病例归在一个关键词下，将便于轻松定位和收集这些病例，并寻找这一现象背后的机制。
