弥合脑胰岛素抵抗与阿尔茨海默病发病机制之间的联系。
Bridging brain insulin resistance to Alzheimer's pathogenesis.
机构信息
Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA; Steno Diabetes Center Copenhagen, Herlev, 2730, Denmark.
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
出版信息
Trends Biochem Sci. 2024 Nov;49(11):939-941. doi: 10.1016/j.tibs.2024.09.004. Epub 2024 Oct 1.
Emerging evidence links type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), with brain insulin resistance (BIR) as a key factor. In a recent study, Lanzillotta et al. reveal that reduced biliverdin reductase-A (BVR-A) impairs glycogen synthase kinase 3β (GSK3β) phosphorylation, causing mitochondrial dysfunction and exacerbating brain insulin resistance in the progression of both T2DM and AD.
新的证据表明 2 型糖尿病（T2DM）和阿尔茨海默病（AD）之间存在关联，而大脑胰岛素抵抗（BIR）则是一个关键因素。在最近的一项研究中，Lanzillotta 等人揭示了低水平的胆绿素还原酶-A（BVR-A）会损害糖原合成酶激酶 3β（GSK3β）的磷酸化，导致线粒体功能障碍，并在 T2DM 和 AD 的进展中加剧大脑胰岛素抵抗。
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