脾脏伤害感受性神经连接促进体液免疫。

Splenic nociceptive neural connection promotes humoral immunity.

作者信息

Qian Cheng, Wang Jiaming, Cao Xuetao

机构信息

National Key Laboratory of Immunity and Inflammation, Institute of Immunology, Naval Medical University, Shanghai, China.

Department of Immunology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

出版信息

Trends Neurosci. 2024 Dec;47(12):968-970. doi: 10.1016/j.tins.2024.09.008. Epub 2024 Oct 2.

DOI:10.1016/j.tins.2024.09.008

PMID:39358065

Abstract

Recent work by Wu and colleagues unveiled a previously enigmatic population of spleen-innervating nociceptors from left T8-T13 dorsal root ganglia (DRGs) in mice. They found a specific DRG-spleen sensorineural connection that promotes humoral immunity via a CGRP-CALCRL/RAMP1 axis, providing a valuable target for immune regulation in local microenvironments.

摘要

吴及其同事最近的研究揭示了小鼠左T8-T13背根神经节（DRG）中一群以前神秘的支配脾脏的伤害感受器。他们发现了一种特定的DRG-脾脏感觉神经连接，该连接通过CGRP-CALCRL/RAMP1轴促进体液免疫，为局部微环境中的免疫调节提供了一个有价值的靶点。