Department of Oncology, University of Oxford, Oxford, UK.
Radcliffe Department of Medicine, Nuffield Division of Clinical Laboratory Science, University of Oxford, Oxford, UK.
Trends Cancer. 2024 Nov;10(11):1038-1051. doi: 10.1016/j.trecan.2024.08.003. Epub 2024 Oct 2.
The classic cancer hallmark, inducing angiogenesis, was born out of the long-held notion that tumours could grow only if new vessels were formed. The attempts, based on this premise, to therapeutically restrain angiogenesis in hopes of controlling tumour growth have been less effective than expected. This is partly because primary and metastatic tumours can grow without angiogenesis. The discovery of nonangiogenic cancers and the mechanisms they use to exploit normal vessels, called 'vessel co-option,' has opened a new field in cancer biology. Consequently, the cancer hallmark, 'inducing angiogenesis,' has been modified to 'inducing or accessing vasculature.'
经典的癌症特征之一——诱导血管生成，源于一个长期以来的观点，即肿瘤只有在形成新血管的情况下才能生长。基于这一前提，人们试图通过治疗性抑制血管生成来控制肿瘤生长，但效果并不如预期。部分原因是原发性和转移性肿瘤可以在没有血管生成的情况下生长。非血管生成性癌症的发现及其利用称为“血管选择”的正常血管的机制，开辟了癌症生物学的一个新领域。因此，癌症特征之一的“诱导血管生成”已被修改为“诱导或利用血管系统”。
