平衡免疫激活与 Itk。
Balancing immune activation with Itk.
机构信息
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Trends Pharmacol Sci. 2024 Nov;45(11):958-960. doi: 10.1016/j.tips.2024.09.005. Epub 2024 Oct 2.
Abstract
Development of protective immune responses relies on a balance between proinflammatory CD4 T helper (Th) cell populations such as Th17 cells and regulatory CD4 T cells (Tregs) that keep immune activation in check. Evidence that interleukin-2-inducible T cell kinase (Itk) regulates this balance supports therapeutic applications for Itk inhibition.
摘要
保护性免疫反应的发展依赖于促炎 CD4 T 辅助（Th）细胞群体（如 Th17 细胞）和调节性 CD4 T 细胞（Tregs）之间的平衡，后者可控制免疫激活。白细胞介素 2 诱导的 T 细胞激酶（Itk）调节这种平衡的证据支持 Itk 抑制的治疗应用。
相似文献
1
Balancing immune activation with Itk.平衡免疫激活与 Itk。
Trends Pharmacol Sci. 2024 Nov;45(11):958-960. doi: 10.1016/j.tips.2024.09.005. Epub 2024 Oct 2.
2
The kinase ITK controls a Ca-mediated switch that balances T17 and T cell differentiation.该激酶 ITK 控制着一个 Ca2+介导的开关，该开关平衡了 T17 和 T 细胞分化。
Sci Signal. 2024 Jul 23;17(846):eadh2381. doi: 10.1126/scisignal.adh2381.
3
Genetic Deficiency and Biochemical Inhibition of ITK Affect Human Th17, Treg, and Innate Lymphoid Cells.ITK 的遗传缺陷和生化抑制作用影响人 Th17、Treg 和固有淋巴细胞。
J Clin Immunol. 2019 May;39(4):391-400. doi: 10.1007/s10875-019-00632-5. Epub 2019 Apr 25.
4
Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells.Itk 介导的 T 细胞受体和细胞因子信号转导调节 Th17 和调节性 T 细胞之间的平衡。
J Exp Med. 2014 Mar 10;211(3):529-43. doi: 10.1084/jem.20131459. Epub 2014 Feb 17.
5
Tuning T helper cell differentiation by ITK.通过 ITK 调节辅助性 T 细胞分化。
Biochem Soc Trans. 2020 Feb 28;48(1):179-185. doi: 10.1042/BST20190486.
6
Blockade of interleukin-2-inducible T-cell kinase signaling attenuates acute lung injury in mice through adjustment of pulmonary Th17/Treg immune responses and reduction of oxidative stress.阻断白细胞介素-2 诱导的 T 细胞激酶信号通路通过调节肺部 Th17/Treg 免疫应答和降低氧化应激减轻小鼠急性肺损伤。
Int Immunopharmacol. 2020 Jun;83:106369. doi: 10.1016/j.intimp.2020.106369. Epub 2020 Mar 9.
7
Exploring the Mechanisms of Lijin Fang on Treg/Th17 Cell Imbalance in COPD Based on Network Pharmacology.基于网络药理学探讨理金方对慢性阻塞性肺疾病中Treg/Th17细胞失衡的作用机制
Int J Chron Obstruct Pulmon Dis. 2025 Jul 5;20:2227-2247. doi: 10.2147/COPD.S512469. eCollection 2025.
8
The Role of T-Helper 17 Cells and Regulatory T Cells in Acute Diffuse and Total Alopecia: The Increased Function of Regulatory T Cells May Explain the Favorable Prognosis.辅助性T细胞17和调节性T细胞在急性弥漫性和全秃中的作用：调节性T细胞功能增强可能解释良好预后。
J Dermatol. 2025 Jul;52(7):1138-1145. doi: 10.1111/1346-8138.17745. Epub 2025 May 24.
9
Plasticity deficits of Tregs remodeling toward Th1-like and Th17-like Tregs in individuals with type 1 diabetes.1型糖尿病患者中调节性T细胞向Th1样和Th17样调节性T细胞重塑的可塑性缺陷
J Endocrinol Invest. 2025 Mar 3. doi: 10.1007/s40618-025-02557-w.
10
Antisense to human CD39 dysregulates immune metabolism in inflammatory bowel disease.针对人类CD39的反义核酸使炎症性肠病中的免疫代谢失调。
Cell Mol Immunol. 2025 May 26. doi: 10.1038/s41423-025-01295-6.
本文引用的文献
1
The kinase ITK controls a Ca-mediated switch that balances T17 and T cell differentiation.该激酶 ITK 控制着一个 Ca2+介导的开关，该开关平衡了 T17 和 T 细胞分化。
Sci Signal. 2024 Jul 23;17(846):eadh2381. doi: 10.1126/scisignal.adh2381.
2
Targeting kinase ITK treats autoimmune arthritis via orchestrating T cell differentiation and function.靶向激酶 ITK 通过调控 T 细胞分化和功能治疗自身免疫性关节炎。
Biomed Pharmacother. 2023 Dec 31;169:115886. doi: 10.1016/j.biopha.2023.115886. Epub 2023 Nov 22.
3
Protein kinases: drug targets for immunological disorders.蛋白激酶：免疫性疾病的药物靶点。
Nat Rev Immunol. 2023 Dec;23(12):787-806. doi: 10.1038/s41577-023-00877-7. Epub 2023 May 15.
4
Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of T9 cells to promote allergic inflammation.动态染色质可及性赋予 T9 细胞依赖 STAT5 和 STAT6 的固有样功能，以促进过敏炎症。
Nat Immunol. 2023 Jun;24(6):1036-1048. doi: 10.1038/s41590-023-01501-5. Epub 2023 Apr 27.
5
CD4 T Helper Cell Subsets and Related Human Immunological Disorders.CD4+ T 辅助细胞亚群及相关人类免疫性疾病。
Int J Mol Sci. 2020 Oct 28;21(21):8011. doi: 10.3390/ijms21218011.
6
Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells.线粒体氧化磷酸化调节致病性 Th17 细胞和调节性 T 细胞之间的命运决定。
Cell Rep. 2020 Feb 11;30(6):1898-1909.e4. doi: 10.1016/j.celrep.2020.01.022.
7
Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells.Itk 介导的 T 细胞受体和细胞因子信号转导调节 Th17 和调节性 T 细胞之间的平衡。
J Exp Med. 2014 Mar 10;211(3):529-43. doi: 10.1084/jem.20131459. Epub 2014 Feb 17.
8
CD28 and ITK signals regulate autoreactive T cell trafficking.CD28 和 ITK 信号调节自身反应性 T 细胞的迁移。
Nat Med. 2013 Dec;19(12):1632-7. doi: 10.1038/nm.3393. Epub 2013 Nov 24.
9
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells.HIF1alpha 依赖性糖酵解途径为 TH17 和 Treg 细胞的分化协调代谢检查点。
J Exp Med. 2011 Jul 4;208(7):1367-76. doi: 10.1084/jem.20110278. Epub 2011 Jun 27.
10
T-cell signaling regulated by the Tec family kinase, Itk.T 细胞信号转导受 Tec 家族激酶 Itk 调节。
Cold Spring Harb Perspect Biol. 2010 Jul;2(7):a002287. doi: 10.1101/cshperspect.a002287. Epub 2010 Jun 2.
Zotero 插件